Literature DB >> 6136992

Cholinergic effects of cimetidine and ranitidine.

L Re, M L Cingolani, C Concettoni, L Rossini.   

Abstract

Cimetidine and ranitidine were submitted to eight in vitro assays: their intrinsic activity was evaluated on guinea-pig auricles and ileum, acetylcholine synergism on guinea-pig tracheal muscle, frog rectus abdominis, guinea-pig vas and rat phrenic nerve diaphragm, and antagonism on guinea-pig auricles and rat jejunum estimated at a range of concentrations. Ranitidine alone opposed 1-hyoscyamine antagonism in guinea-pig ileum when acetylcholine was the agonist, but not when the agonist was bethanechol.

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Year:  1983        PMID： 6136992     DOI： 10.1016/s0031-6989(83)80068-x

Source DB:  PubMed          Journal:  Pharmacol Res Commun        ISSN： 0031-6989


  5 in total

1.  A comparison of the cholinergic activity of selected H2-antagonists and sulfoxide metabolites.

Authors:  J W Kosh; J W Sowell; J M Chapman
Journal:  Pharm Res       Date:  1989-08       Impact factor: 4.200

2.  Ranitidine and nizatidine stimulate antral smooth muscle contractility via excitatory cholinergic mechanisms.

Authors:  H P Parkman; A P Pagano; J P Ryan
Journal:  Dig Dis Sci       Date:  1998-03       Impact factor: 3.199

3.  The effect of stimulation and blocking of histamine H2 receptors on the turnover of the serotonin in different parts of the alimentary tract and the brain of the rat.

Authors:  B Skrzydło-Radomańska; J Pokora; Z Kleinrok; P Radwan
Journal:  Agents Actions       Date:  1985-04

Review 4.  Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.

Authors:  S M Grant; H D Langtry; R N Brogden
Journal:  Drugs       Date:  1989-06       Impact factor: 9.546

5.  First-degree atrioventricular block in a young duodenal ulcer patient treated with a standard oral dose of ranitidine.

Authors:  G Allegri; K Pellegrini; G Dobrilla
Journal:  Agents Actions       Date:  1988-07
  5 in total

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