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Literature DB >> 6135912

Reversal of hepatic alpha-1-antitrypsin deposition after portacaval shunt.

T E Starzl, K A Porter, A Francavilla, S Iwatsuki.

Abstract

End-to-side portacaval shunts were carried out in three children with the liver disease of alpha-1-antitrypsin deficiency and complications of portal hypertension. Their clinical courses have been stable for 3 1/2 to almost 7 years. Postoperative liver biopsy material from two of the patients showed the typical histopathological changes caused by portal diversion, as well as an apparent reduction in the quantity of alpha-1-antitrypsin particles in the hepatocytes. The metabolic changes caused by portal diversion have apparently created a more favourable equilibrium between the synthesis and excretion of the abnormal alpha-1-antitrypsin.

Entities: Disease Gene Species

Mesh：

Year: 1983 PMID： 6135912 PMCID： PMC2981405 DOI： 10.1016/s0140-6736(83)90390-2

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

18 in total

1. Basis of the defect in alpha-1-antitrypsin deficiency.

Authors: O F Bell; R W Carrell
Journal: Nature Date: 1973-06-15 Impact factor: 49.962

2. Demonstration of sialyltransferase deficiency in the serum of a patient with alpha-1-antitrypsin deficiency and hepatic cirrhosis.

Authors: M S Kuhlenschmidt; E J Yunis; R M Iammarino; S J Turco; S P Peters; R H Glew
Journal: Lab Invest Date: 1974-10 Impact factor: 5.662

3. Pathology and pathogenesis of liver disease in alpha-1-antitrypsin deficient individuals.

Authors: O Aagenaes; M TFagerhol; K Elgjo; E Munthe; T Hovig
Journal: Postgrad Med J Date: 1974-06 Impact factor: 2.401

4. The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood.

Authors: T E Starzl; A Francavilla; C G Halgrimson; F R Francavilla; K A Porter; T H Brown; C W Putnam
Journal: Surg Gynecol Obstet Date: 1973-08

5. Portacaval shunt in hyperlipoproteinaemia.

Authors: T E Starzl; C W Putnam; H P Chase; K A Porter
Journal: Lancet Date: 1973-10-27 Impact factor: 79.321

6. Portal diversion for the treatment of glycogen storage disease in humans.

Authors: T E Starzl; C W Putnam; K A Porter; C G Halgrimson; J Corman; B I Brown; R W Gotlin; D O Rodgerson; H L Greene
Journal: Ann Surg Date: 1973-10 Impact factor: 12.969

7. Studies on acute phase proteins of rat serum. IV. Pathway of secretion of albumin and alpha1-acid glycoprotein from liver.

Authors: J C Jamieson; F E Ashton
Journal: Can J Biochem Date: 1973-09

8. Biosynthesis of glycoprotein by liver. The incorporation in vivo of 14C-glucosamine into protein-bound hexosamine and sialic acid of rat liver subcellular fractions.

Authors: G R Lawford; H Schachter
Journal: J Biol Chem Date: 1966-11-25 Impact factor: 5.157

9. Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs.

Authors: T E Starzl; K Watanabe; K A Porter; C W Putnam
Journal: Lancet Date: 1976-04-17 Impact factor: 79.321

Reversal of hepatic alpha-1-antitrypsin deposition after portacaval shunt.

1. Basis of the defect in alpha-1-antitrypsin deficiency.

2. Demonstration of sialyltransferase deficiency in the serum of a patient with alpha-1-antitrypsin deficiency and hepatic cirrhosis.

3. Pathology and pathogenesis of liver disease in alpha-1-antitrypsin deficient individuals.

4. The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood.

5. Portacaval shunt in hyperlipoproteinaemia.

6. Portal diversion for the treatment of glycogen storage disease in humans.

7. Studies on acute phase proteins of rat serum. IV. Pathway of secretion of albumin and alpha1-acid glycoprotein from liver.

8. Biosynthesis of glycoprotein by liver. The incorporation in vivo of 14C-glucosamine into protein-bound hexosamine and sialic acid of rat liver subcellular fractions.

9. Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs.

Review 10. The current status of alpha-1-antityrpsin, a protease inhibitor, in gastrointestinal disease.

1. The mother lode of liver transplantation, with particular reference to our new journal.

Review 2. Association of alpha 1-antitrypsin deficiency with lung and liver diseases.

Review 3. Alpha-1-antitrypsin deficiency: current concepts.

4. The Eck fistula in animals and humans.