Literature DB >> 6135580

Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine.

J P Lehman, C Fenselau, J R Depaulo.   

Abstract

The quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine were shown to be conjugated in vitro using an immobilized rabbit hepatic microsomal enzyme preparation. It was shown that fast atom bombardment mass spectrometry could be used for direct characterization of these involatile, thermally labile metabolites. The quaternary ammonium-linked glucuronides of amitriptyline and imipramine were demonstrated to be present in urine from patients receiving therapeutic doses of these tricyclic antidepressants.

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Year:  1983        PMID： 6135580

Source DB:  PubMed          Journal:  Drug Metab Dispos        ISSN： 0090-9556            Impact factor:   3.922


  4 in total

1.  OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation.

Authors:  Ryan R Hughes; Khaled A Shaaban; Jianjun Zhang; Hongnan Cao; George N Phillips; Jon S Thorson
Journal:  Chembiochem       Date:  2017-01-09       Impact factor: 3.164

2.  The analysis and disposition of imipramine and its active metabolites in man.

Authors:  T A Sutfin; C L DeVane; W J Jusko
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

3.  Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies.

Authors:  P Baumann; J M Gaillard; M Jonzier-Perey; C Gerber; C Bouras
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

4.  Urinary excretion of conjugates of dothiepin and northiaden (mono-N-demethyl-dothiepin) after an oral dose of dothiepin to humans.

Authors:  K Kawahara; T Awaji; K Uda; Y Sakai; Y Hashimoto
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Jan-Mar       Impact factor: 2.441
  4 in total

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