Literature DB >> 6135325

In vivo inhibition of phospholipase A2 in rat lung by an beta-adrenergic agonist.

P V Wichert, W Meyer.   

Abstract

Phospholipase A2 is the key enzyme for the release of arachidonic acid derived mediators via cycloxygenase or lipoxygenase pathways in inflammation and immunological processes. Activity of microsomal phospholipase A2 in rat lung can be inhibited by in vivo application of the beta-adrenergic drug fenoterol both in control and diseased animals.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6135325     DOI： 10.1007/bf01967339

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  Control of lung surfactant by ventilation, adrenergic mediators, and prostaglandins in the rabbit.

Authors:  M J Oyarzun; J A Clements
Journal:  Am Rev Respir Dis       Date:  1978-05

2.  Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation.

Authors:  R J Flower; G J Blackwell
Journal:  Nature       Date:  1979-03-29       Impact factor: 49.962

3.  Impaired pulmonary surfactant synthesis in starvation and severe nonthoracic sepsis.

Authors:  J W Rubin; G H Clowes; M F Macnicol; J W Gavin
Journal:  Am J Surg       Date:  1972-04       Impact factor: 2.565

4.  Studies on the arachidonic acid cascade--I. Inhibition of phospholipase A2 in vitro and in vivo by several novel series of inhibitor compounds.

Authors:  D P Wallach; V J Brown
Journal:  Biochem Pharmacol       Date:  1981-06-01       Impact factor: 5.858

5.  Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to beta-adrenergic stimulation.

Authors:  L G Dobbs; R J Mason
Journal:  J Clin Invest       Date:  1979-03       Impact factor: 14.808

6.  Altered metabolism of phospholipids in the lung of rats with peritonitis.

Authors:  P von Wichert; U Wiegers; W Stephan; A Huck; P Eckert; K Riesner
Journal:  Res Exp Med (Berl)       Date:  1978-06-12

7.  Influence of septic shock upon phosphatidylcholine remodeling mechanism in rat lung.

Authors:  P von Wichert; M Temmesfeld; W Meyer
Journal:  Biochim Biophys Acta       Date:  1981-06-23

8.  Pulmonary injury and prostaglandin production during endotoxemia in conscious sheep.

Authors:  R H Demling; M Smith; R Gunther; J T Flynn; M H Gee
Journal:  Am J Physiol       Date:  1981-03
  8 in total
  2 in total

Review 1.  Prostaglandins and the lung.

Authors:  S P Hanley
Journal:  Lung       Date:  1986       Impact factor: 2.584

2.  Electrophysiological effects of tachykinins and capsaicin on guinea-pig bronchial parasympathetic ganglion neurones.

Authors:  A C Myers; B J Undem
Journal:  J Physiol       Date:  1993-10       Impact factor: 5.182
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.