Literature DB >> 6134766

Radioligand receptor assay for TSH and TSH-binding-inhibiting antibodies using solubilized TSH-receptor.

P Kotulla, C Kostner, H Schleusener.   

Abstract

A radioligand receptor assay (RRA) for TSH and TSH-binding-inhibiting antibodies (TBIAb) using solubilized receptor is presented. Introducing charcoal for separation of bound and free hormone has made the assay easier to handle. The detection limit for TSH is 30 microU/ml as measured by RIA. TBIAb was found in the sera of 19 of 26 hyperthyroid patients. Only 16 sera were positive when the RRA using membrane fragments was applied.

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Year:  1983        PMID: 6134766     DOI: 10.1007/BF03350586

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN: 0391-4097            Impact factor:   4.256


  9 in total

1.  Clinical application of a radioreceptor assay for thyroid stimulators.

Authors:  H Schleusener; P Kotulla; F Adlkofer; S S Nussey; S Q Mehdi
Journal:  Horm Metab Res       Date:  1975-07       Impact factor: 2.936

2.  Glandular end organ deficiency associated with secretion of biologically inactive pituitary peptides.

Authors:  D T Krieger
Journal:  J Clin Endocrinol Metab       Date:  1974-06       Impact factor: 5.958

3.  The thyrotrophin receptor in guinea-pig thyroid homogenate: general properties.

Authors:  S W Manley; J R Bourke; R W Hawker
Journal:  J Endocrinol       Date:  1974-06       Impact factor: 4.286

4.  Thyroid-stimulating immunoglobulins in Graves' disease.

Authors:  B R Smith; R Hall
Journal:  Lancet       Date:  1974-08-24       Impact factor: 79.321

5.  Relationship between thyroid status and Graves' disease-specific immunoglobulins.

Authors:  H Schleusener; P Kotulla; R Finke; H Sörje; H Meinhold; F Adlkofer; K W Wenzel
Journal:  J Clin Endocrinol Metab       Date:  1978-08       Impact factor: 5.958

6.  Thyrotropin secretion in patients with central hypothyroidism: evidence for reduced biological activity of immunoreactive thyrotropin.

Authors:  G Faglia; L Bitensky; A Pinchera; C Ferrari; A Paracchi; P Beck-Peccoz; B Ambrosi; A Spada
Journal:  J Clin Endocrinol Metab       Date:  1979-06       Impact factor: 5.958

7.  Abnormal thyroid stimulating hormone following pituitary surgery.

Authors:  G K Worth; R W Retallack; D H Gutteridge
Journal:  J Endocrinol Invest       Date:  1981 Apr-Jun       Impact factor: 4.256

8.  The secretion of thyrotrophin with impaired biological activity in patients with hypothalamic-pituitary disease.

Authors:  V B Petersen; A M McGregor; P E Belchetz; R S Elkeles; R Hall
Journal:  Clin Endocrinol (Oxf)       Date:  1978-05       Impact factor: 3.478

9.  Solubilized TSH-receptor: its usefulness for the radioligand receptor assay for TSH and TSH-displacing antibody.

Authors:  P Kotulla; H Schleusener
Journal:  J Endocrinol Invest       Date:  1981 Apr-Jun       Impact factor: 4.256

  9 in total

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