Literature DB >> 6133910

Muscarinic receptor compensation in hippocampus of Alzheimer patients.

A Nordberg, C Larsson, R Adolfsson, I Alafuzoff, B Winblad.   

Abstract

The activity of the acetylcholine synthesizing enzyme choline acetyltransferase (ChAT) (presynaptic marker) and number of muscarine-like receptor binding sites have been measured in the hippocampus from eight individuals with senile dementia of Alzheimer type (SDAT) and ten controls. A negative correlation (r = 0.80; p less than 0.05) was found between the ChAT activity and the number of muscarine-like receptors in the SDAT group but not in the controls. The findings might indicate an ongoing compensatory receptor mechanism as a response to changes in presynaptic cholinergic activity.

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Year:  1983        PMID： 6133910     DOI： 10.1007/bf01243370

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  19 in total

1.  Dendritic sprouting in Alzheimer's presenile dementia.

Authors:  A B Scheibel; U Tomiyasu
Journal:  Exp Neurol       Date:  1978-05-15       Impact factor: 5.330

2.  Determination of 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and homovanillic acid in brain tissue from an autopsy material.

Authors:  C G Gottfries; B E Roos; B Winblad
Journal:  Acta Psychiatr Scand       Date:  1974       Impact factor: 6.392

3.  Postsynaptic localization of muscarinic cholinergic receptor binding in rat hippocampus.

Authors:  H I Yamamura; S H Snyder
Journal:  Brain Res       Date:  1974-09-27       Impact factor: 3.252

4.  Muscarinic supersensitivity induced by septal lesion or chronic atropine treatment.

Authors:  A Westlind; M Grynfarb; B Hedlund; T Bartfai; K Fuxe
Journal:  Brain Res       Date:  1981-11-23       Impact factor: 3.252

5.  Cholinergic receptors in human hippocampus-- regional distribution and variance with age.

Authors:  A Nordberg; B Winblad
Journal:  Life Sci       Date:  1981-11-09       Impact factor: 5.037

6.  The cholinergic system in old age and Alzheimer's disease.

Authors:  E K Perry
Journal:  Age Ageing       Date:  1980-02       Impact factor: 10.668

7.  Muscarinic binding and choline acetyltransferase activity in Parkinsonian subjects with reference to dementia.

Authors:  M Ruberg; A Ploska; F Javoy-Agid; Y Agid
Journal:  Brain Res       Date:  1982-01-28       Impact factor: 3.252

8.  Prevalence of dementia disorders in institutionalized Swedish old people. The work load imposed by caring for these patients.

Authors:  R Adolfsson; C G Gottfries; L Nyström; B Winblad
Journal:  Acta Psychiatr Scand       Date:  1981-03       Impact factor: 6.392

9.  Glucose metabolism and acetylcholine synthesis in relation to neuronal activity in Alzheimer's disease.

Authors:  N R Sims; D M Bowen; C C Smith; R H Flack; A N Davison; J S Snowden; D Neary
Journal:  Lancet       Date:  1980-02-16       Impact factor: 79.321

10.  Titration of human brain monoamine oxidase -A and -B by clorgyline and L-deprenil.

Authors:  C J Fowler; L Oreland; J Marcusson; B Winblad
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-04       Impact factor: 3.000
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  10 in total

1.  Cholinergic nicotinic systems in Alzheimer's disease: prospects for pharmacological intervention.

Authors:  Robyn Vesey; Jennifer M Birrell; Clare Bolton; Ruth S Chipperfield; Andrew D Blackwell; Tom R Dening; Barbara J Sahakian
Journal:  CNS Drugs       Date:  2002       Impact factor: 5.749

2.  Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia.

Authors:  E D London; M J Ball; S B Waller
Journal:  Neurochem Res       Date:  1989-08       Impact factor: 3.996

3.  Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multi-infarct dementia.

Authors:  E Perdahl; R Adolfsson; I Alafuzoff; K A Albert; E J Nestler; P Greengard; B Winblad
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575

4.  Increased CSF HVA response to arecoline challenge in Alzheimer's disease.

Authors:  N Pomara; M Stanley; P A LeWitt; M Galloway; R Singh; D Deptula
Journal:  J Neural Transm Gen Sect       Date:  1992

5.  Differential cholinergic regulation in Alzheimer's patients compared to controls following chronic blockade with scopolamine: a SPECT study.

Authors:  T Sunderland; G Esposito; S E Molchan; R Coppola; D W Jones; J Gorey; J T Little; M Bahro; D R Weinberger
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530

6.  Cholinergic topography in Alzheimer brains: a comparison with changes in the monoaminergic profile.

Authors:  A Nordberg; P Nyberg; R Adolfsson; B Winblad
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

7.  A comparison of brain choline acetyltransferase activity in Alzheimer's disease, multi-infarct dementia, and combined dementia.

Authors:  J O Rinne; E Säkö; L Paljärvi; P K Mölsä; U K Rinne
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

8.  Compensatory responses to age-related decline in odor quality acuity: cholinergic neuromodulation and olfactory enrichment.

Authors:  Nathalie Mandairon; Shane T Peace; Karim Boudadi; Christine E Boxhorn; Venkata Anupama Narla; Sara D Suffis; Thomas A Cleland
Journal:  Neurobiol Aging       Date:  2010-01-15       Impact factor: 4.673

9.  Effects of a single dose of the acetylcholinesterase inhibitor velnacrine on recognition memory and regional cerebral blood flow in Alzheimer's disease.

Authors:  K P Ebmeier; R Hunter; S M Curran; N J Dougal; C L Murray; D J Wyper; J Patterson; M T Hanson; K Siegfried; G M Goodwin
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

10.  5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases.

Authors:  G P Reynolds; S L Mason; A Meldrum; S De Keczer; H Parnes; R M Eglen; E H Wong
Journal:  Br J Pharmacol       Date:  1995-03       Impact factor: 8.739
  10 in total

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