Literature DB >> 6133540

Factors influencing the activity and fate of benzodiazepines in the body.

E van der Kleijn, T B Vree, A M Baars, R Wijsman, L C Edmunds, H J Knop.   

Abstract

1 The clinical pharmacokinetics of the many benzodiazepines used to treat numerous and varied clinical conditions can be influenced by many factors. 2 Combinations of drugs efficacious in the central nervous system can change the onset, intensity and duration of effect as a result of pharmacological, physiological and pharmacokinetic actions. 3 Pharmacokinetic considerations indicate that short to medium long-acting benzodiazepines that depend on only glucuronidation for their major metabolic pathway are the drugs of choice in this category.

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Year:  1981        PMID： 6133540      PMCID： PMC1401632          DOI： 10.1111/j.1365-2125.1981.tb01843.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  32 in total

1.  An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain.

Authors:  A Guidotti; G Toffano; E Costa
Journal:  Nature       Date:  1978-10-12       Impact factor: 49.962

2.  Autoradiographic localisation of benzodiazepine receptors in the brains of humans and animals.

Authors:  W S Young; M J Kuhar
Journal:  Nature       Date:  1979-08-02       Impact factor: 49.962

3.  [Impairment of performance by alcohol and diazepam (author's transl)].

Authors:  J Lutze; H P Gelbke; G Schmidt
Journal:  Z Rechtsmed       Date:  1979-03-08

4.  Central mechanisms of tranquilizing, anticonvulsant and relaxant actions of RO4-5360.

Authors:  R Hernández-Peón; J A Rojas-Ramírez
Journal:  Int J Neuropharmacol       Date:  1966-05

5.  Pharmacodynamic consequences of aging and their implications in the treatment of the elderly patient.

Authors:  A D Bender
Journal:  Med Ann Dist Columbia       Date:  1967-05

6.  Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.

Authors:  T B Vree; A M Baars; Y A Hekster; E van der Kleijn; W J O'Reilly
Journal:  J Chromatogr       Date:  1979-04-11

7.  Phenytoin intoxication during concurrent diazepam therapy.

Authors:  H J Rogers; R A Haslam; J Longstreth; P S Lietman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1977-09       Impact factor: 10.154

8.  Hypnotic activity of 3-hydroxy, N-desmethyldiazepam (oxazepam).

Authors:  A N Nicholson; B M Stone
Journal:  Br J Clin Pharmacol       Date:  1978-05       Impact factor: 4.335

9.  Effect of active metabolites of chlordiazepoxide and diazepam, alone or in combination with alcohol, on psychomotor skills related to driving.

Authors:  E S Palva; M Linnoila
Journal:  Eur J Clin Pharmacol       Date:  1978-07-30       Impact factor: 2.953

10.  Effects of diazepam on succinylcholine-induced myalgia, potassium increase, creatine phosphokinase elevation, and relaxation.

Authors:  M Eisenberg; S Balsley; R L Katz
Journal:  Anesth Analg       Date:  1979 Jul-Aug       Impact factor: 5.108
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  2 in total

1.  Isolation and identification of 4-hydroxysulfamerazine and preliminary studies on its pharmacokinetics in dogs.

Authors:  T B Vree; M W Tijhuis; J F Nouws; Y A Hekster
Journal:  Pharm Weekbl Sci       Date:  1984-04-27

2.  Benzodiazepine Use Is Associated With an Increased Risk of Neurocognitive Impairment in People Living With HIV.

Authors:  Rowan Saloner; David J Grelotti; Griffin Tyree; Erin E Sundermann; Qing Ma; Scott Letendre; Robert K Heaton; Mariana Cherner
Journal:  J Acquir Immune Defic Syndr       Date:  2019-12-15       Impact factor: 3.771
  2 in total

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