Literature DB >> 6133513

Effects of amitriptyline on serum glutamate and free tryptophan in rats.

J S Kim, W Schmid-Burgk, D Claus, H H Kornhuber.   

Abstract

In rats, chronic amitriptyline (14 days, 10 mg/kg, IP) administration resulted in a significant increase in the serum glutamate concentration and concomitant increase in the serum free tryptophan. In contrast, amitriptyline had no effect on the total serum tryptophan or CSF glutamate level. The data confirmed that antidepressant drugs may induce an increase of the serum glutamate concentration in depressive patients.

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Year:  1982        PMID： 6133513     DOI： 10.1007/bf00345595

Source DB:  PubMed          Journal:  Arch Psychiatr Nervenkr (1970)


  11 in total

1.  INHIBITION OF UPTAKE OF TRITIATED-NORADRENALINE IN THE INTACT RAT BRAIN BY IMIPRAMINE AND STRUCTURALLY RELATED COMPOUNDS.

Authors:  J GLOWINSKI; J AXELROD
Journal:  Nature       Date:  1964-12-26       Impact factor: 49.962

Review 2.  On the slowness of action of tricyclic antidepressant drugs.

Authors:  I Oswald; V Brezinova; D L Dunleavy
Journal:  Br J Psychiatry       Date:  1972-06       Impact factor: 9.319

3.  Fluorometric determination of aspartate, glutamate, and gamma-aminobutyrate in nerve tissue using enzymic methods.

Authors:  L T Graham; M H Aprison
Journal:  Anal Biochem       Date:  1966-06       Impact factor: 3.365

4.  Error in the determination of tryptophan by the method of Denkla and Dewey. A revised procedure.

Authors:  D L Bloxam; W H Warren
Journal:  Anal Biochem       Date:  1974-08       Impact factor: 3.365

5.  A method for the estimation of free and total acid-soluble plasma tryptophan using an ultrafiltration technique.

Authors:  E G Eccleston
Journal:  Clin Chim Acta       Date:  1973-10-30       Impact factor: 3.786

6.  Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine.

Authors:  A Carlsson; H Corrodi; K Fuxe; T Hökfelt
Journal:  Eur J Pharmacol       Date:  1969-03       Impact factor: 4.432

7.  Uptake mechanisms for neurotransmitter amines.

Authors:  L L Iversen
Journal:  Biochem Pharmacol       Date:  1974-07-15       Impact factor: 5.858

8.  Tricyclic antidepressant agents. I. Comparison of the inhibition of the uptake of 3-H-noradrenaline and 14-C-5-hydroxytryptamine in slices and crude synaptosome preparations of the midbrain-hypothalamus region of the rat brain.

Authors:  S B Ross; A L Renyi
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1975

9.  Presynaptic adrenergic receptor sensitivity in depression. The effect of long-term desipramine treatment.

Authors:  D S Charney; G R Heninger; D E Sternberg; D E Redmond; J F Leckman; J W Maas; R H Roth
Journal:  Arch Gen Psychiatry       Date:  1981-12

10.  Differential effect of chronic desipramine and amitriptyline treatment on rat brain adrenergic and serotonergic receptors.

Authors:  S W Tang; P Seeman; S Kwan
Journal:  Psychiatry Res       Date:  1981-04       Impact factor: 3.222
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  2 in total

Review 1.  Review of pharmacological treatment in mood disorders and future directions for drug development.

Authors:  Xiaohua Li; Mark A Frye; Richard C Shelton
Journal:  Neuropsychopharmacology       Date:  2011-09-07       Impact factor: 7.853

Review 2.  Microglial Cells as a Link between Cannabinoids and the Immune Hypothesis of Psychiatric Disorders.

Authors:  Sabrina F Lisboa; Felipe V Gomes; Francisco S Guimaraes; Alline C Campos
Journal:  Front Neurol       Date:  2016-01-28       Impact factor: 4.003
  2 in total

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