Literature DB >> 6133351

Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.

D P van Kammen, L S Mann, D E Sternberg, M Scheinin, P T Ninan, S R Marder, W B van Kammen, R O Rieder, M Linnoila.   

Abstract

Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.

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Year:  1983        PMID： 6133351     DOI： 10.1126/science.6133351

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  All-night electroencephalographic sleep and cranial computed tomography in depression. A study of unipolar and bipolar patients.

Authors:  C J Lauer; M Wiegand; J C Krieg
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1992       Impact factor: 5.270

Review 2.  Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia.

Authors:  A A Grace
Journal:  J Neural Transm Gen Sect       Date:  1993

3.  Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates.

Authors:  J D Elsworth; D J Leahy; R H Roth; D E Redmond
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

4.  Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition.

Authors:  L Ugedo; J Grenhoff; T H Svensson
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530
  4 in total

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