Literature DB >> 6132634

Effect of prolonged beta-adrenoceptor blockade on heart weight and ultrastructure in young rabbits.

W G Nayler, A Slade, E M Vaughan Williams, C E Yepez.   

Abstract

1 Young rabbits were treated for 30 days or 6 weeks with propranolol or oxprenolol to provide dose-levels similar to those used clinically. 2 Relative to litter matched controls the treated rabbits exhibited a reduced rate of growth. 3 Morphometric studies showed that prolonged beta-adrenoceptor blockade had no effect on the myofibrillar volume as a proportion of cell volume. 4 Prolonged beta-blockade increased the proportion of the extracellular space occupied by vascular tissue.

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Year:  1980        PMID： 6132634      PMCID： PMC2044194          DOI： 10.1111/j.1476-5381.1980.tb14549.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  The effects of prolonged beta-adrenoceptor blockade on heart weight and cardiac intracellular potentials in rabbits.

Authors:  E M Williams; A E Raine; A A Cabrera; J M Whyte
Journal:  Cardiovasc Res       Date:  1975-09       Impact factor: 10.787

2.  Long term beta-adrenergic blockade reduces tyrosine hydroxylase and dopamine beta-hydroxylase activities in sympathetic ganglia.

Authors:  A E Raine; I W Chubb
Journal:  Nature       Date:  1977-05-19       Impact factor: 49.962

3.  THE EFFECTS ON CARDIAC MUSCLE OF BETA-RECEPTOR ANTAGONISTS IN RELATION TO THEIR ACTIVITY AS LOCAL ANAESTHETICS.

Authors:  A MORALES AGUILERA; E M VAUGHANWILLIAMS
Journal:  Br J Pharmacol Chemother       Date:  1965-04

4.  Cardiovascular and sympathetic response to exercise after long-term beta-adrenergic blockade.

Authors:  A E Raine; T G Pickering
Journal:  Br Med J       Date:  1977-07-09

5.  Beta-adrenoceptor antagonists and the release of creatine phosphokinase from hypoxic heart muscle.

Authors:  W G Nayler; A Grau; C Yepez
Journal:  Cardiovasc Res       Date:  1977-07       Impact factor: 10.787

6.  A protective effect of verapamil on hypoxic heart muscle.

Authors:  W G Nayler; A Grau; A Slade
Journal:  Cardiovasc Res       Date:  1976-11       Impact factor: 10.787

7.  Morphometric changes in rabbit ventricular myocardium produced by long-term beta-adrenoceptor blockade.

Authors:  E M Williams; J Tasgal; A E Raine
Journal:  Lancet       Date:  1977-10-22       Impact factor: 79.321
  7 in total
  4 in total

1.  The effect of prolonged propranolol administration on myocardial transmural capillary density in young rabbits.

Authors:  J Tasgal; E M Williams
Journal:  J Physiol       Date:  1981-06       Impact factor: 5.182

2.  Adaptation of hypertensives to treatment with cardioselective and non-selective beta-blockers. Absence of correlation between bradycardia and blood pressure control, and reduction in slope of the QT/RR relation.

Authors:  E M Williams; M O Hassan; J S Floras; P Sleight; J V Jones
Journal:  Br Heart J       Date:  1980-11

3.  Hypoxic cardiac hypertrophy is not inhibited by cardioselective or non-selective beta-adrenoceptor antagonists.

Authors:  P Dennis; E M Vaughan Williams
Journal:  J Physiol       Date:  1982-03       Impact factor: 5.182

4.  Quantitative 31P nuclear magnetic resonance analysis of metabolite concentrations in Langendorff-perfused rabbit hearts.

Authors:  J K Gard; G M Kichura; J J Ackerman; J D Eisenberg; J J Billadello; B E Sobel; R W Gross
Journal:  Biophys J       Date:  1985-11       Impact factor: 4.033
  4 in total

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