| Literature DB >> 6132317 |
W Y Fujimoto, S Kawazu, M Ikeuchi, Y Kanazawa.
Abstract
In monolayer cultures of islet cells from neonatal rats, incubation of cells for 1 hour with either anti-somatostatin serum or anti-glucagon serum enhanced insulin release. The former appears to be due to neutralization of endogenously secreted somatostatin. The latter may be due to removal of a stimulatory effect of endogenously released glucagon upon somatostatin secretion. Thus, although exogenously added glucagon stimulates insulin secretion, the effect of endogenously released glucagon upon islet B cells is a restraining one which may be mediated through an effect upon D cells and their release of endogenous somatostatin.Entities:
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Year: 1983 PMID： 6132317 DOI： 10.1016/0024-3205(83)90066-8
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037