| Literature DB >> 6131547 |
B A Gorshkov, I A Gorshkova, T N Makarieva, V A Stonik.
Abstract
The bromine-containing compounds from sponges of the Aplysinidae family inhibit, in vitro, the Na+ -K+ -ATPase activity of the rat brain microsomal fraction. The extent of inhibition is dependent on concentration and chemical structure of the compounds. The substances containing the dienone fragment, such as 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-acetamide (IV), 3,5-dibromo-1-acetoxy-4-oxo-2,5-cyclohexadien-1-acetonitrile (V) and 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-ethylacetate (VI), are powerful inhibitors of Na+ -K+ -ATPase.Entities:
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Year: 1982 PMID： 6131547 DOI： 10.1016/0041-0101(82)90113-1
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033