Literature DB >> 6131536

An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons.

M M Slaughter, R F Miller.   

Abstract

cis-2,3-Piperidinedicarboxylic acid (PDA), an excitatory amino acid antagonist, reversibly blocked cone input to OFF bipolars and horizontal cells, whereas ON bipolars were relatively unaffected. Kainic acid effects were also blocked, indicating a postsynaptic mechanism of action. The use of PDA helps to characterize one of two classes of excitatory amino acid synaptic receptors that mediate cone influence in the outer retina.

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Year:  1983        PMID： 6131536     DOI： 10.1126/science.6131536

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  51 in total

1.  Functional architecture of synapses in the inner retina: segregation of visual signals by stratification of bipolar cell axon terminals.

Authors:  S M Wu; F Gao; B R Maple
Journal:  J Neurosci       Date:  2000-06-15       Impact factor: 6.167

2.  Assessment of local cone on- and off-pathway function using multifocal ERG technique.

Authors:  M Kondo; Y Miyake
Journal:  Doc Ophthalmol       Date:  2000       Impact factor: 2.379

3.  Effects of APB, PDA, and TTX on ERG responses recorded using both multifocal and conventional methods in monkey. Effects of APB, PDA, and TTX on monkey ERG responses.

Authors:  William A Hare; Hau Ton
Journal:  Doc Ophthalmol       Date:  2002-09       Impact factor: 2.379

4.  The ERG of guinea pig (Cavis porcellus): comparison with I-type monkey and E-type rat.

Authors:  Bo Lei
Journal:  Doc Ophthalmol       Date:  2003-05       Impact factor: 2.379

5.  Organizational motifs for ground squirrel cone bipolar cells.

Authors:  Adam C Light; Yongling Zhu; Jun Shi; Shannon Saszik; Sarah Lindstrom; Laura Davidson; Xiaoyu Li; Vince A Chiodo; William W Hauswirth; Wei Li; Steven H DeVries
Journal:  J Comp Neurol       Date:  2012-09-01       Impact factor: 3.215

6.  Effects of Spectral Characteristics of Ganzfeld Stimuli on the Photopic Negative Response (PhNR) of the ERG.

Authors:  Nalini V Rangaswamy; Suguru Shirato; Muneyoshi Kaneko; Beth I Digby; John G Robson; Laura J Frishman
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-10       Impact factor: 4.799

7.  Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos.

Authors:  N Dale; A Roberts
Journal:  J Physiol       Date:  1985-06       Impact factor: 5.182

8.  Effect of excitatory amino acids and analogues on [3H]acetylcholine release from amacrine cells of the rabbit retina.

Authors:  J R Cunningham; M J Neal
Journal:  J Physiol       Date:  1985-09       Impact factor: 5.182

9.  Synaptic transmission at N-methyl-D-aspartate receptors in the proximal retina of the mudpuppy.

Authors:  P D Lukasiewicz; J S McReynolds
Journal:  J Physiol       Date:  1985-10       Impact factor: 5.182

10.  Ionotropic non-N-methyl-D-aspartate agonists induce retraction of dendritic spinules from retinal horizontal cells.

Authors:  R Weiler; K Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205
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