Literature DB >> 6130458

Inhibition of dibutyryl cyclic AMP-induced insulin release by alpha-2 adrenergic stimulation.

T Nakaki, T Nakadate, S Yamamoto, R Kato.   

Abstract

Effects of alpha adrenergic agonists and antagonists on dibutyryl cAMP (Bt2cAMP)-induced insulin release were investigated with isolated rat pancreatic islets. Bt2cAMP (4 mM) produced 2-fold stimulation of insulin release in all the concentrations of glucose examined (3.3-16.7 mM). Clonidine but not phenylephrine inhibited the Bt2cAMP-stimulated insulin release in a concentration-dependent manner with approximate EC50 of nanomolar range. Yohimbine but not prazosin antagonized the inhibitory effect of clonidine on the Bt2-cAMP-induced insulin release. These results suggest that alpha-2 adrenergic mechanisms are involved in a step distal to cAMP generation.

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Year:  1983        PMID： 6130458     DOI： 10.1016/0024-3205(83)90030-9

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  7 in total

1.  Amitraz-induced glucose intolerance in rats: antagonism by yohimbine but not by prazosin.

Authors:  B E Smith; W H Hsu; P C Yang
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

2.  Effects of Bordetella pertussis toxin on catecholamine inhibition of insulin release from intact and electrically permeabilized rat islets.

Authors:  S J Persaud; P M Jones; S L Howell
Journal:  Biochem J       Date:  1989-03-15       Impact factor: 3.857

Review 3.  The role of cyclic AMP in insulin release.

Authors:  W J Malaisse; F Malaisse-Lagae
Journal:  Experientia       Date:  1984-10-15

4.  Comparison of the inhibition of insulin release by activation of adenosine and alpha 2-adrenergic receptors in rat beta-cells.

Authors:  G Bertrand; M Nenquin; J C Henquin
Journal:  Biochem J       Date:  1989-04-01       Impact factor: 3.857

5.  Studies on the mechanism of inhibition of glucose-stimulated insulin secretion by noradrenaline in rat islets of Langerhans.

Authors:  N G Morgan; W Montague
Journal:  Biochem J       Date:  1985-03-01       Impact factor: 3.857

6.  Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat.

Authors:  R J Lacey; N S Berrow; J H Scarpello; N G Morgan
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

7.  Role of alpha 1- and alpha 2-adrenoceptors in catecholamine-induced hyperglycaemia, lipolysis and insulin secretion in conscious fasted rabbits.

Authors:  J Moratinos; C Carpene; I de Pablos; M Reverte
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739
  7 in total

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