Literature DB >> 6130154

Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.

P W Erhardt, C M Woo, W G Anderson, R J Gorczynski.   

Abstract

Several short-acting beta-adrenergic receptor blocking agents have been prepared by incorporating ester functions into the aryl portion of certain (aryloxy)propanolamine systems. In particular, methyl 3-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]propionate hydrochloride (ASL-8052) was found to be a moderately potent, cardioselective compound with a short duration of action when determined in in vivo canine models.

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Year:  1982        PMID： 6130154     DOI： 10.1021/jm00354a003

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  8 in total

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Review 4.  Structural Modification in Anesthetic Drug Development for Prodrugs and Soft Drugs.

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Review 5.  Esmolol. A review of its therapeutic efficacy and pharmacokinetic characteristics.

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6.  Soft drugs. XX. Design, synthesis, and evaluation of ultra-short acting beta-blockers.

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7.  Esmolol, an ultrashort-acting, selective beta 1-adrenoceptor antagonist: pharmacodynamic and pharmacokinetic properties.

Authors:  C Volz-Zang; B Eckrich; P Jahn; B Schneidrowski; B Schulte; D Palm
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

8.  Synthesis and biological evaluation of indolyl-pyridinyl-propenones having either methuosis or microtubule disruption activity.

Authors:  Christopher J Trabbic; Jean H Overmeyer; Evan M Alexander; Emily J Crissman; Heather M Kvale; Marcie A Smith; Paul W Erhardt; William A Maltese
Journal:  J Med Chem       Date:  2015-02-19       Impact factor: 7.446
  8 in total

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