Literature DB >> 6129728

May enzyme activity in urine play a role in kidney stone formation?

R Azoury, N Garti, S Perlberg, S Sarig.   

Abstract

It has been found that calcium oxalate stone formers have low UGOT and UGPT activity compared to healthy individuals. The urine of 23 stone formers and 19 controls has been tested for combined UGOT and UGPT activity. The effect of L-aspartic acid, alanine and L-glutamic acid on calcium oxalate precipitation has been tested. Only L-glutamic acid exerted a significant retardation effect at physiological concentrations. As GPT and GOT convert alanine and aspartic acid respectively into glutamic acid, a possible mechanism of retardation of kidney stone formation involving enzyme steps via glutamic acid creation in situ is suggested.

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Year:  1982        PMID： 6129728     DOI： 10.1007/bf00255942

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  9 in total

1.  The urinary amino acids in relation to calculus disease.

Authors:  M G McGEOWN
Journal:  J Urol       Date:  1957-10       Impact factor: 7.450

2.  Growth of calcium oxalate crystals. II. Inhibition by natural urinary crystal growth inhibitors.

Authors:  J L Meyer; L H Smith
Journal:  Invest Urol       Date:  1975-07

3.  A quantitative investigation of the effects on the growth of calcium oxalate crystals on potential inhibitors.

Authors:  S G Welshman; M G McGeown
Journal:  Br J Urol       Date:  1972-12

4.  Calcium oxalate crystalluria and inhibitors of crystallization in recurrent renal stone-formers.

Authors:  W G Robertson; M Peacock
Journal:  Clin Sci       Date:  1972-10       Impact factor: 6.124

5.  Genetic predisposition to formation of calcium oxalate renal calculi.

Authors:  M Resnick; D B Pridgen; H O Goodman
Journal:  N Engl J Med       Date:  1968-06-13       Impact factor: 91.245

6.  The inhibitory effect of polymeric carboxylic amino-acids and urine on calcium oxalate crystallization.

Authors:  N Garti; F Tibika; S Sarig; S Perlberg
Journal:  Biochem Biophys Res Commun       Date:  1980-12-16       Impact factor: 3.575

7.  Crystal growth inhibitors in human urine. Effect on calcium oxalate kinetics.

Authors:  G L Gardner; R H Doremus
Journal:  Invest Urol       Date:  1978-05

8.  Retardation of calcium oxalate formation by polyacidic peptides.

Authors:  N Garti; S Sarig; F Tibika
Journal:  Invest Urol       Date:  1980-09

9.  Control of oxalate urolithiasis by DL-alanine.

Authors:  F C Chow; M I Dysart; D W Hamar; R H Udall
Journal:  Invest Urol       Date:  1975-09
  9 in total
  4 in total

1.  Evaluation of the relative inhibitory potential of fractionated urinary macromolecules.

Authors:  R Azoury; B Goldwasser; Y Wax; S Perlberg; N Garti; S Sarig
Journal:  Urol Res       Date:  1985

2.  Determination of GOT activity on nucleation and crystal growth of calcium oxalate.

Authors:  R Azoury; S Sarig; N Garti; S Perlberg; A D Randolph; G W Drach
Journal:  Urol Res       Date:  1984

Review 3.  The amino acid factor in stone formers' and normal urines.

Authors:  R Azoury; N Garti; S Sarig
Journal:  Urol Res       Date:  1986

4.  Retardation of calcium oxalate precipitation by glutamic-oxalacetic-transaminase activity.

Authors:  R Azoury; S Sarig; N Garti; S Perlberg
Journal:  Urol Res       Date:  1982
  4 in total

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