Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antibodies to human leucocyte interferons in cancer patients.

Literature DB >> 6129455

Antibodies to human leucocyte interferons in cancer patients.

P W Trown, M J Kramer, R A Dennin, E V Connell, A V Palleroni, J Quesada, J U Gutterman.

Abstract

During the course of clinical investigation of partly purified human leucocyte interferon (IFN) prepared at the Finnish Red Cross (PIF), neutralising IgG antibodies to human leucocyte IFN were detected in the sera of 3 patients with cancer. In 2 of these patients, the antibodies were detected in serum before treatment with PIF. In the third patient antibodies developed during the course of treatment. Antibody titres against six recombinant human leucocyte IFN sub-types and one recombinant hybrid human leucocyte IFN were different in the 3 patients.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6129455 DOI： 10.1016/s0140-6736(83)91737-3

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

Keyword Cloud
Cited

20 in total

1. Neutralizing antibodies to granulocyte-macrophage colony-stimulating factor, interleukin-1alpha and interferon-alpha but not other cytokines in human immunoglobulin preparations.

Authors: M Wadhwa; A Meager; P Dilger; C Bird; C Dolman; R G Das; R Thorpe
Journal: Immunology Date: 2000-01 Impact factor: 7.397

Review 2. The relevance of pharmacokinetics in the development of biotechnology products.

Authors: S Toon
Journal: Eur J Drug Metab Pharmacokinet Date: 1996 Apr-Jun Impact factor: 2.441

3. Autoantibodies to crude human leucocyte interferon (IFN), native human IFN, recombinant human IFN-alpha 2b and human IFN-gamma in healthy blood donors.

Authors: C Ross; M B Hansen; T Schyberg; K Berg
Journal: Clin Exp Immunol Date: 1990-10 Impact factor: 4.330

Review 4. Interferons, a group of multiple lymphokines.

Authors: H Kirchner
Journal: Springer Semin Immunopathol Date: 1984

5. Pilot study of recombinant interferon alpha-2a for treatment of infants with bronchiolitis induced by respiratory syncytial virus.

Authors: J Portnoy; R Hicks; F Pacheco; L Olson
Journal: Antimicrob Agents Chemother Date: 1988-04 Impact factor: 5.191

6. VH and V kappa segment structure of anti-insulin IgG autoantibodies in patients with insulin-dependent diabetes mellitus. Evidence for somatic selection.

Authors: H Ikematsu; Y Ichiyoshi; E W Schettino; M Nakamura; P Casali
Journal: J Immunol Date: 1994-02-01 Impact factor: 5.422

Antibodies to human leucocyte interferons in cancer patients.

1. Neutralizing antibodies to granulocyte-macrophage colony-stimulating factor, interleukin-1alpha and interferon-alpha but not other cytokines in human immunoglobulin preparations.

Review 2. The relevance of pharmacokinetics in the development of biotechnology products.

3. Autoantibodies to crude human leucocyte interferon (IFN), native human IFN, recombinant human IFN-alpha 2b and human IFN-gamma in healthy blood donors.

Review 4. Interferons, a group of multiple lymphokines.

5. Pilot study of recombinant interferon alpha-2a for treatment of infants with bronchiolitis induced by respiratory syncytial virus.

6. VH and V kappa segment structure of anti-insulin IgG autoantibodies in patients with insulin-dependent diabetes mellitus. Evidence for somatic selection.

7. Naturally occurring anti-interferon-alpha 2a antibodies in patients with acute viral hepatitis.

8. Binding of cytokines to pharmaceutically prepared human immunoglobulin.

9. Assessment of the antigenic response in humans to a recombinant mutant interferon beta.

10. Phase II trial of recombinant leukocyte A interferon in advanced malignant melanoma.