Literature DB >> 6129175

Oxytocin-induced Ca-free contraction of rat uterine smooth muscle: effects of preincubation with EGTA and drugs.

K Sakai, K Higuchi, T Yamaguchi, M Uchida.   

Abstract

1. The effect of the time of preincubation with 3 mM EGTA on oxytocin-induced Ca-free contraction of rat uterus was investigated. It was found 10(-2) unit/ml oxytocin induced sustained Ca-free contraction only after preincubation for 50 min or more. 2. The tension developed showed a biphasic relation to the time of preincubation with a minimum at 25 min. 3. Sustained Ca-free contraction could be repeated with only slight reduction in magnitude. 4. Oxytocin-induced Ca-free contraction was relaxed by isoproterenol. The effect of isoproterenol was inhibited by 3 X 10(-4) M 1,1-diphenyl-3-piperazino-1-butanol hydrochloride.

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Year:  1982        PMID： 6129175     DOI： 10.1016/0306-3623(82)90104-5

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  7 in total

1.  The response of non-pregnant rat myometrium to oxytocin in Ca-free solution.

Authors:  F Ashoori; A Takai; T Tomita
Journal:  Br J Pharmacol       Date:  1985-01       Impact factor: 8.739

2.  Contractions of rat uterine smooth muscle induced by acetylcholine and angiotensin II in Ca2+-free medium.

Authors:  C Lalanne; C Mironneau; J Mironneau; J P Savineau
Journal:  Br J Pharmacol       Date:  1984-02       Impact factor: 8.739

3.  The spasmogenic action of oxytocin in the rat uterus--comparison with other agonists.

Authors:  D Edwards; D M Good; S E Granger; M Hollingsworth; A Robson; R C Small; A H Weston
Journal:  Br J Pharmacol       Date:  1986-08       Impact factor: 8.739

4.  Maintained contractions of rat uterine smooth muscle incubated in a Ca2+-free solution.

Authors:  C Mironneau; J Mironneau; J P Savineau
Journal:  Br J Pharmacol       Date:  1984-07       Impact factor: 8.739

5.  Gestational changes in the utilization of intracellularly stored calcium in the myometrium of guinea-pigs.

Authors:  H A Coleman; P G McShane; H C Parkington
Journal:  J Physiol       Date:  1988-05       Impact factor: 5.182

6.  Carbachol-induced contraction in the circular muscle of guinea-pig stomach in calcium-free solution.

Authors:  F Ashoori; H Hidaka; T Tomita
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

7.  Tonic contraction of canine gastric muscle during long-lasting calcium removal and its dependence on magnesium.

Authors:  K Filipponi; K Golenhofen; V Hofstetter; J Hohnsbein; E Lammel; J Lukanow
Journal:  J Physiol       Date:  1987-12       Impact factor: 5.182
  7 in total

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