Literature DB >> 6128754

Neuroleptic drug effect on platelet monoamine oxidase and plasma amine oxidase in schizophrenia.

M Baron, R Gruen, M Levitt, J Kane.   

Abstract

Activity levels of platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) were determined in eight chronic schizophrenic patients who had been treated with neuroleptic drugs for 3 months. The mean reduction in platelet MAO activity was 18.6%. The extent of decrease was statistically significant. The reduction in enzyme activity was unrelated to serum iron levels. PAO activity was unaltered. The implications for schizophrenia research are discussed.

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Year:  1982        PMID： 6128754     DOI： 10.1016/0165-1781(92)90091-g

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  4 in total

1.  Monoamine oxidase gene transcription in human cell lines: treatment with psychoactive drugs and ethanol.

Authors:  J Ekblom; Q S Zhu; K Chen; J C Shih
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

2.  Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia.

Authors:  J Fang; P H Yu; J W Gorrod; A A Boulton
Journal:  Psychopharmacology (Berl)       Date:  1995-03       Impact factor: 4.530

Review 3.  Implication of the polyamine system in mental disorders.

Authors:  Laura M Fiori; Gustavo Turecki
Journal:  J Psychiatry Neurosci       Date:  2008-03       Impact factor: 6.186

Review 4.  Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy.

Authors:  Hans-Gert Bernstein; Gerburg Keilhoff; Gregor Laube; Henrik Dobrowolny; Johann Steiner
Journal:  World J Psychiatry       Date:  2021-12-19
  4 in total

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