Literature DB >> 6128235

Forskolin stimulates renin release from the isolated perfused rat kidney.

U Schwertschlag, E Hackenthal.   

Abstract

Forskolin, a novel receptor-independent adenylate cyclase activator, stimulated renin release from the isolated perfused rat kidney twofold at 10(-7) M and threefold at 10(-6) M. This stimulation was blocked by angiotensin II but not by the beta-adrenoceptor antagonist atenolol. These findings strengthen the concept that an intracellular increase of 3',5'-cyclic AMP by adenylate cyclase activation can induce stimulation of renin release.

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Year:  1982        PMID： 6128235     DOI： 10.1016/0014-2999(82)90165-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Differences between high-affinity forskolin binding sites in dopamine-rich and other regions of rat brain.

Authors:  J A Poat; H E Cripps; L L Iversen
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

Review 2.  Novel mechanisms for the control of renin synthesis and release.

Authors:  Maria Luisa S Sequeira Lopez; R Ariel Gomez
Journal:  Curr Hypertens Rep       Date:  2010-02       Impact factor: 5.369

3.  Forskolin and calcium: interactions in the control of renin secretion and perfusate flow in the isolated rat kidney.

Authors:  J C Fray; C S Park
Journal:  J Physiol       Date:  1986-06       Impact factor: 5.182

4.  Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release.

Authors:  Douglas K Atchison; Pamela Harding; M Cecilia Ortiz-Capisano; Edward L Peterson; William H Beierwaltes
Journal:  Am J Physiol Renal Physiol       Date:  2012-08-15

5.  Renin release and gene expression in intact rat kidney microvessels and single cells.

Authors:  A D Everett; R M Carey; R L Chevalier; M J Peach; R A Gomez
Journal:  J Clin Invest       Date:  1990-07       Impact factor: 14.808

Review 6.  The role of calcium in the regulation of renin secretion.

Authors:  William H Beierwaltes
Journal:  Am J Physiol Renal Physiol       Date:  2009-07-29

7.  Regulation of prorenin secretion in cultured human transfected juxtaglomerular cells.

Authors:  F Pinet; J Mizrahi; I Laboulandine; J Menard; P Corvol
Journal:  J Clin Invest       Date:  1987-09       Impact factor: 14.808

8.  Forskolin and the release of noradrenaline in cerebrocortical slices.

Authors:  R Markstein; K Digges; N R Marshall; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-01       Impact factor: 3.000
  8 in total

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