Literature DB >> 6127224

Suppression of withdrawal symptoms by dynorphin in heroin addicts.

H L Wen, W K Ho.   

Abstract

The effectiveness of dynorphin-(1-13) in suppressing heroin withdrawal was studied. At a dose of 60 micrograms/kg body weight, dynorphin-(1-13) was effective in suppressing withdrawal symptoms. When saline was administered a strong placebo effect was noticed that, however, did not influence the outcome of the results. Only three out of the twelve patients receiving dynorphin-(1-13) experienced some mild side-effects such as feeling warm, dizziness and precordial formication.

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Year:  1982        PMID： 6127224     DOI： 10.1016/0014-2999(82)90509-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

1.  Nicotine may reinforce intravenous drug-taking behavior in drug users: a comment on Harvey et al. (2004).

Authors:  Reuven Dar; Hanan Frenk
Journal:  Psychopharmacology (Berl)       Date:  2004-12-24       Impact factor: 4.530

2.  Metabolism of dynorphin A1-13 in human CSF.

Authors:  S Müller; B L Grundy; G Hochhaus
Journal:  Neurochem Res       Date:  1996-10       Impact factor: 3.996

3.  Stabilized dynorphin derivatives for modulating antinociceptive activity in morphine tolerant rats: effect of different routes of administration.

Authors:  Brugos Brugos; Vikram Arya; Guenther Hochhaus
Journal:  AAPS J       Date:  2004-12-28       Impact factor: 4.009

4.  Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse.

Authors:  Andrew C H Chen; K Steven LaForge; Ann Ho; Pauline F McHugh; Scott Kellogg; Kathy Bell; Rosemary P Schluger; Suzanne M Leal; Mary Jeanne Kreek
Journal:  Am J Med Genet       Date:  2002-05-08

5.  Identification of stabilized dynorphin derivatives for suppressing tolerance in morphine-dependent rats.

Authors:  Suliman I Al-Fayoumi; Boglarka Brugos; Vikram Arya; Esther Mulder; Barbel Eppler; Andre P Mauderli; Günther Hochhaus
Journal:  Pharm Res       Date:  2004-08       Impact factor: 4.200

6.  Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain.

Authors:  Shuanglin Hao; Jian Hu; David J Fink
Journal:  Behav Brain Res       Date:  2008-08-12       Impact factor: 3.332

Review 7.  Do smokers self-administer pure nicotine? A review of the evidence.

Authors:  Reuven Dar; Hanan Frenk
Journal:  Psychopharmacology (Berl)       Date:  2004-03-05       Impact factor: 4.530

8.  Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan.

Authors:  S J Livingston; R D Sewell; K F Rooney; H J Smith
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

Review 9.  Acupuncture for the treatment of drug addiction.

Authors:  Cai-Lian Cui; Liu-Zhen Wu; Fei Luo
Journal:  Neurochem Res       Date:  2008-07-10       Impact factor: 3.996

Review 10.  kappa-Opioid receptor signaling and brain reward function.

Authors:  Adrie W Bruijnzeel
Journal:  Brain Res Rev       Date:  2009-10-02
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