| Literature DB >> 6126240 |
J M Allen, N D Christofides, P A Cramer, J Steinert, S R Bloom.
Abstract
Constipation is a frequent effect of treatment with antidepressant and neuroleptic drugs as a result of interference with neuronal control of colonic muscular activity. Motilin, a circulating peptide, is involved in induction of myoelectric complexes in the colon. Significantly elevated circulating basal motilin levels were found in patients receiving tricyclic antidepressant drugs, mean 128 +/- 33 pmol/l (control 48 +/- 6 pmol/l) or neuroleptic therapy, mean 213 +/- 29 pmol/l (control 87 +/- 8 pmol/l).Entities:
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Year: 1982 PMID： 6126240 DOI： 10.1192/bjp.141.1.27
Source DB: PubMed Journal: Br J Psychiatry ISSN： 0007-1250 Impact factor: 9.319