Literature DB >> 6126101

Flubendazole versus mebendazole in intestinal helminthic infections.

H Feldmeier, U Bienzle, E Döhring, M Dietrich.   

Abstract

In a double-blind study the vermicidal effect of flubendazole, a new benzimidazole derivative, was evaluated and compared to mebendazole. Both drugs were administered in a single dose of 600 mg. While in the treatment of Ascaris and hookworm infestations flubendazole and mebendazole showed a similar efficacy, mebendazole seemed to be slightly superior in the treatment of trichuriasis. Both drugs were well tolerated and no side effects were observed even in patients with a heavy worm load.

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Year:  1982        PMID： 6126101

Source DB:  PubMed          Journal:  Acta Trop        ISSN： 0001-706X            Impact factor:   3.112


  8 in total

1.  Differential efficacy of mebendazole and albendazole against Necator americanus but not for Trichuris trichiura infestations.

Authors:  B R Holzer; F J Frey
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

2.  Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen.

Authors:  Martin Michaelis; Bishr Agha; Florian Rothweiler; Nadine Löschmann; Yvonne Voges; Michel Mittelbronn; Tatjana Starzetz; Patrick N Harter; Behnaz A Abhari; Simone Fulda; Frank Westermann; Kristoffer Riecken; Silvia Spek; Klaus Langer; Michael Wiese; Wilhelm G Dirks; Richard Zehner; Jaroslav Cinatl; Mark N Wass; Jindrich Cinatl
Journal:  Sci Rep       Date:  2015-02-03       Impact factor: 4.379

Review 3.  Repurposing of Drug Candidates for Treatment of Skin Cancer.

Authors:  Hernán Cortés; Octavio D Reyes-Hernández; Sergio Alcalá-Alcalá; Sergio A Bernal-Chávez; Isaac H Caballero-Florán; Maykel González-Torres; Javad Sharifi-Rad; Manuel González-Del Carmen; Gabriela Figueroa-González; Gerardo Leyva-Gómez
Journal:  Front Oncol       Date:  2021-01-08       Impact factor: 6.244

Review 4.  Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers.

Authors:  Chaoran Chen; Yueming Ding; Huiyang Liu; Mengyao Sun; Honggang Wang; Dongdong Wu
Journal:  Int J Mol Sci       Date:  2022-01-04       Impact factor: 5.923

5.  Investigating Flubendazole as an Anthelmintic Treatment for Guinea Worm (Dracunculus medinensis): Clinical Trials in Laboratory-Reared Ferrets and Domestic Dogs in Chad.

Authors:  Christopher A Cleveland; Kayla B Garrett; Erin K Box; Alec T Thompson; Ellen K Haynes; Deborah L Elder; Robert L Richards; Ania A Majewska; Sarah Anne J Guagliardo; Ryan E Wiegand; John A Bryan Ii; Fernando Torres-Velez; Karmen Unterwegner; Mario Romero; Hubert Zirimwabagabo; Metinou Sidouin; Philip Tchindebet Oaukou; Mbang Mahammat Ada; Bongo Nare Richard Ngandolo; Charles D Mackenzie; Timothy G Geary; Adam J Weiss; Michael J Yabsley
Journal:  Am J Trop Med Hyg       Date:  2022-02-28       Impact factor: 3.707

6.  Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity.

Authors:  David J Tweats; George E Johnson; Ivan Scandale; James Whitwell; Dean B Evans
Journal:  Mutagenesis       Date:  2015-10-06       Impact factor: 3.000

7.  Repurposing drugs to fast-track therapeutic agents for the treatment of cryptococcosis.

Authors:  Megan Truong; Leigh G Monahan; Dee A Carter; Ian G Charles
Journal:  PeerJ       Date:  2018-05-04       Impact factor: 2.984

8.  The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer.

Authors:  Rosalba Florio; Serena Veschi; Viviana di Giacomo; Sara Pagotto; Simone Carradori; Fabio Verginelli; Roberto Cirilli; Adriano Casulli; Antonino Grassadonia; Nicola Tinari; Amelia Cataldi; Rosa Amoroso; Alessandro Cama; Laura De Lellis
Journal:  Cancers (Basel)       Date:  2019-12-17       Impact factor: 6.639
  8 in total

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