Literature DB >> 6126003

Quantitative electron microscopic autoradiography of insulin, glucagon, and somatostatin binding sites on islets.

Y C Patel, M Amherdt, L Orci.   

Abstract

After monolayer cultures of rat islets were exposed to [(125)I]insulin,[(125)I]glucagon, and [(125)I]tyrosinyl somatostatin, specific autoradiographic grains associated with each radioactively labeled ligand were found on B, A, and D cells. The density of labeling of the B, A, and D cells with each labeled ligand correlated well with the known actions of the three hormones on each of the islet cells.

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Year:  1982        PMID： 6126003     DOI： 10.1126/science.6126003

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

Review 1.  Receptor imaging in the diagnosis and treatment of pituitary tumors.

Authors:  D J Kwekkeboom; W W de Herder; E P Krenning
Journal:  J Endocrinol Invest       Date:  1999-01       Impact factor: 4.256

2.  Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells.

Authors:  M Amherdt; Y C Patel; L Orci
Journal:  J Clin Invest       Date:  1989-08       Impact factor: 14.808

Review 3.  Islet cell interactions with pancreatic B-cells.

Authors:  D Pipeleers
Journal:  Experientia       Date:  1984-10-15

4.  Expression of insulin receptor on clonal pancreatic alpha cells and its possible role for insulin-stimulated negative regulation of glucagon secretion.

Authors:  K Kisanuki; H Kishikawa; E Araki; T Shirotani; M Uehara; S Isami; S Ura; H Jinnouchi; N Miyamura; M Shichiri
Journal:  Diabetologia       Date:  1995-04       Impact factor: 10.122

Review 5.  The role of cyclic AMP in insulin release.

Authors:  W J Malaisse; F Malaisse-Lagae
Journal:  Experientia       Date:  1984-10-15

6.  In situ binding of islet hormones in the isolated perfused rat pancreas: evidence for local high concentrations of islet hormones via the islet-acinar axis.

Authors:  A Nakagawa; J I Stagner; E Samols
Journal:  Diabetologia       Date:  1995-03       Impact factor: 10.122

7.  Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line.

Authors:  J Philippe
Journal:  J Clin Invest       Date:  1989-08       Impact factor: 14.808

Review 8.  Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients.

Authors:  E P Krenning; D J Kwekkeboom; W H Bakker; W A Breeman; P P Kooij; H Y Oei; M van Hagen; P T Postema; M de Jong; J C Reubi
Journal:  Eur J Nucl Med       Date:  1993-08

Review 9.  Tracer imaging in lung cancer.

Authors:  H M Abdel-Dayem; A Scott; H Macapinlac; S Larson
Journal:  Eur J Nucl Med       Date:  1994-01

10.  Abnormal glucagon response to arginine and its normalization in obese hyperinsulinaemic patients with glucose intolerance: importance of insulin action on pancreatic alpha cells.

Authors:  T Hamaguchi; H Fukushima; M Uehara; S Wada; T Shirotani; H Kishikawa; K Ichinose; K Yamaguchi; M Shichiri
Journal:  Diabetologia       Date:  1991-11       Impact factor: 10.122
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