| Literature DB >> 6125563 |
M Goldstein, A Lieberman, J Pearson.
Abstract
The dopamine levels were found to be low in the putamen and relatively high in the nucleus accumbens in two Parkinson disease patients treated with levodopa up to the time of their deaths. Tyrosine hydroxylase immunocytochemistry revealed a severe degeneration of the nigro-striatal dopamine neuronal system in both postmortem brains. The relatively high dopamine levels in the nucleus accumbens may be responsible for the occurrence of dyskinesias.Entities:
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Year: 1982 PMID： 6125563 DOI： 10.1007/bf01249286
Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575