Literature DB >> 6124972

Immunocytochemical localization of gamma-glutamyltransferase in rat kidney with protein A-horseradish peroxidase.

H W Spater, M S Poruchynsky, N Quintana, M Inoue, A B Novikoff.   

Abstract

Immunocytochemistry with a specific antiserum and protein A-horseradish peroxidase permits visualization of the sites of gamma-glutamyltransferase [(5-glutamyl)-peptide:amino-acid 5-glutamyltransferase, EC 2.3.2.2] at both the light- and the electron-microscope levels. As seen by light microscopy, the enzyme is localized only in the proximal convolutions of the renal tubules. Electron microscopy reveals dense deposits of 3,3'-diaminobenzidine reaction product embedded in the glycocalyx along the entire luminal surface of the microvilli and in the basolateral membranes.

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Year:  1982        PMID： 6124972      PMCID： PMC346458          DOI： 10.1073/pnas.79.11.3547

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  GAMMA-GLUTAMYL-P-NITROANILIDE: A NEW CONVENIENT SUBSTRATE FOR DETERMINATION AND STUDY OF L- AND D-GAMMA-GLUTAMYLTRANSPEPTIDASE ACTIVITIES.

Authors:  M ORLOWSKI; A MEISTER
Journal:  Biochim Biophys Acta       Date:  1963-08-06

2.  Affinity labeling of rat kidney gamma-glutamyl transpeptidase by 6-diazo-5-oxo-D-norleucine.

Authors:  M Inoue; S Horiuchi; Y Morino
Journal:  Eur J Biochem       Date:  1979-08-15

3.  Diffusion artificats in 3,3'-diaminobenzidine cytochemistry.

Authors:  A B Novikoff; P M Novikoff; N Quintana; C Davis
Journal:  J Histochem Cytochem       Date:  1972-09       Impact factor: 2.479

4.  Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity.

Authors:  A M Rutenburg; H Kim; J W Fischbein; J S Hanker; H L Wasserkrug; A M Seligman
Journal:  J Histochem Cytochem       Date:  1969-08       Impact factor: 2.479

5.  Latent active site in rat-kidney gamma-glutamyl transpeptidase. The refolding process of the large subunit and characterization of the renatured enzyme.

Authors:  S Horiuchi; M Inoue; Y Morino
Journal:  Eur J Biochem       Date:  1980-03

6.  Direct evidence for inter-organ transport of glutathione and that the non-filtration renal mechanism for glutathione utilization involves gamma-glutamyl transpeptidase.

Authors:  M E Anderson; R J Bridges; A Meister
Journal:  Biochem Biophys Res Commun       Date:  1980-09-30       Impact factor: 3.575

7.  The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.

Authors:  R C Graham; M J Karnovsky
Journal:  J Histochem Cytochem       Date:  1966-04       Impact factor: 2.479

8.  Immunocytochemical localization of epoxide hydrase in hyperplastic nodules induced in rat liver by 2-acetylaminofluorene.

Authors:  A B Novikoff; P M Novikoff; R J Stockert; F F Becker; A Yam; M S Poruchynsky; W Levin; P E Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

Review 9.  New aspects of glutathione metabolism and translocation in mammals.

Authors:  A Meister; O W Griffith; A Novogrodsky; S S Tate
Journal:  Ciba Found Symp       Date:  1979

10.  Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (DAB).

Authors:  A M Seligman; M J Karnovsky; H L Wasserkrug; J S Hanker
Journal:  J Cell Biol       Date:  1968-07       Impact factor: 10.539
  10 in total
  17 in total

1.  Differentiation of metanephric tubules following a short transfilter induction pulse.

Authors:  Eero Lehtonen; Hannu Jalanko; Liisa Laitinen; Aaro Miettinen; Peter Ekblom; Lauri Saxén
Journal:  Wilehm Roux Arch Dev Biol       Date:  1983-05

2.  gamma-Glutamyltranspeptidase from Proteus mirabilis: localization and activation by phospholipids.

Authors:  R Nakayama; H Kumagai; T Tochikura
Journal:  J Bacteriol       Date:  1984-12       Impact factor: 3.490

3.  Identification of high molecular weight antigens structurally related to gamma-glutamyl transferase in epithelial tissues.

Authors:  J D Castle; R S Cameron; P L Patterson; A K Ma
Journal:  J Membr Biol       Date:  1985       Impact factor: 1.843

Review 4.  Glutathione metabolism in the pancreas compared with that in the liver, kidney, and small intestine.

Authors:  S Githens
Journal:  Int J Pancreatol       Date:  1991-02

5.  Immunocytochemical study of seminal gamma-glutamyltransferase using monoclonal antibodies.

Authors:  S Abe; H Gunji; T Fujita; K Hiraiwa
Journal:  Cell Tissue Res       Date:  1994-07       Impact factor: 5.249

6.  Cell proliferation induced in the kidneys and livers of rats and mice by short term exposure to the carcinogen p-dichlorobenzene.

Authors:  T Umemura; K Tokumo; G M Williams
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

7.  Renal cysts and associated renal tumours in male ddY mice injected with ferric nitrilotriacetate.

Authors:  A Kondo; J Deguchi; S Okada
Journal:  Virchows Arch       Date:  1995       Impact factor: 4.064

8.  Immunocytochemical localization of gamma-glutamyl-transferase on isolated renal cortical tubular fragments.

Authors:  W Pfaller; G Gstraunthaler; P Kotanko; H Wolf; N P Curthoys
Journal:  Histochemistry       Date:  1984

9.  Does superoxide underlie the pathogenesis of hypertension?

Authors:  K Nakazono; N Watanabe; K Matsuno; J Sasaki; T Sato; M Inoue
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

Review 10.  Cytochemistry of membrane proteases.

Authors:  R Gossrau
Journal:  Histochem J       Date:  1985-07
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