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Literature DB >> 6124449

Glutathione and gamma-glutamyl cycle enzymes in rat mammary gland.

Abstract

The main enzymes of the gamma-glutamyl cycle during the lactogenic cycle in rat mammary gland were studied. A significant increase was found in all of them with the onset of lactogenesis. The effect of methionine sulfoximine on reduced glutathione concentration was studied in tissue slices of lactating mammary gland. The findings suggest that this compound effects glutathione synthesis by inhibiting gamma-glutamylcysteine synthetase.

Entities: Chemical Gene Species

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Year: 1982 PMID： 6124449 DOI： 10.1007/bf02327032

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

14 in total

Review 1. Glutathione and related gamma-glutamyl compounds: biosynthesis and utilization.

Authors: A Meister; S S Tate
Journal: Annu Rev Biochem Date: 1976 Impact factor: 23.643

2. Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats.

Authors: A G Palekar; S S Tate; A Meister
Journal: Biochem Biophys Res Commun Date: 1975-02-03 Impact factor: 3.575

3. Gamma-glutamyltranspeptidase activity and cyclic AMP levels in rat liver and mammary gland during the lactogenic cycle and in the oestradiol-progesterone pseudo-induced pregnancy.

Authors: J Puente; M A Varas; G Beckhaus; M Sapag-Hagar
Journal: FEBS Lett Date: 1979-03-01 Impact factor: 4.124

4. Isolation of highly purified gamma-glutamylcysteine synthetase from rat kidney.

Authors: M Orlowski; A Meister
Journal: Biochemistry Date: 1971-02-02 Impact factor: 3.162

5. The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.

Authors: L F Chasseaud
Journal: Adv Cancer Res Date: 1979 Impact factor: 6.242

6. Intermediates of the gamma-glutamyl cycle in mouse tissues. Influence of administration of amino acids on pyrrolidone carboxylate and gamma-glutamyl amino acids.

Authors: M Orlowski; S Wilk
Journal: Eur J Biochem Date: 1975-05-06

7. Estimation and identification of thiols in rat spleen after cysteine or glutathione treatment: relevance to protection against nitrogen mustards.

Authors: C R Ball
Journal: Biochem Pharmacol Date: 1966-07 Impact factor: 5.858

Glutathione and gamma-glutamyl cycle enzymes in rat mammary gland.

Review 1. Glutathione and related gamma-glutamyl compounds: biosynthesis and utilization.

2. Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats.

3. Gamma-glutamyltranspeptidase activity and cyclic AMP levels in rat liver and mammary gland during the lactogenic cycle and in the oestradiol-progesterone pseudo-induced pregnancy.

4. Isolation of highly purified gamma-glutamylcysteine synthetase from rat kidney.

5. The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.

6. Intermediates of the gamma-glutamyl cycle in mouse tissues. Influence of administration of amino acids on pyrrolidone carboxylate and gamma-glutamyl amino acids.

7. Estimation and identification of thiols in rat spleen after cysteine or glutathione treatment: relevance to protection against nitrogen mustards.

8. Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.

9. Properties of gamma-glutamyltranspeptidase, and glutathione levels in rat mammary gland.

10. 5-Oxoprolinase from rat kidney, I. Assay, purification, and determination of kinetic parameters.

1. Effect of hormones and cyclic AMP on gamma-glutamyltranspeptidase activity of rat mammary gland explants.

2. Enzymes of mercapturic acid production in rat mammary gland.

3. Glutathione-related enzyme activities in pregnant rat liver.