| Literature DB >> 6124433 |
K C Retz, A C Young, J T Coyle.
Abstract
The effects of acidic excitatory amino acids and 60 mM K+ on 45Ca uptake by synaptosomes prepared from rat striatum were examined. Both glutamic acid and 60 mM K+ significantly stimulated the uptake of 45Ca and these effects were antagonized by 30 mM Mg2+ and 0.5 mM La3+ but not by 5 microM tetrodotoxin. Neither kainic acid nor N-methyl-D,L-aspartic acid significantly affected the uptake of 45Ca. The results suggest that glutamate may activate a presynaptic receptor that is directly linked to calcium channels.Entities:
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Year: 1982 PMID： 6124433 DOI： 10.1016/0014-2999(82)90640-9
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432