Literature DB >> 612437

Effect of various treatments on toxicity of inhaled vinylidene chloride.

R D Short, J M Winston, J L Minor, J Seifter, C C Lee.   

Abstract

The toxicity of vinylidene chloride (VDC) was studied in mice and rats exposed to various concentrations of the vapors for 23 hr/day. In addition, the ability of various treatments to alter parameters of toxicity was evaluated. Mice were more sensitive than rats both to the acute lethal and hepatotoxic effects of VDC. Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC. Treatment with diethyldithiocarbamate and thiram also protected mice from the acute lethal effects of VDC.

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Year:  1977        PMID： 612437      PMCID： PMC1475354          DOI： 10.1289/ehp.7721125

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  19 in total

1.  METABOLISM OF DISULFIRAM AND DIETHYLDITHIOCARBAMATE IN RATS WITH DEMONSTRATION OF AN IN VIVO ETHANOL-INDUCED INHIBITION OF THE GLUCURONIC ACID CONJUGATION OF THE THIOL.

Authors:  J H STRUME
Journal:  Biochem Pharmacol       Date:  1965-04       Impact factor: 5.858

2.  Serum glutamic-oxaloacetic transaminase activity. A new modification and an anaytical assessment of current assay technics.

Authors:  E AMADOR; W E WACKER
Journal:  Clin Chem       Date:  1962-08       Impact factor: 8.327

3.  Revised spectrophotometric methods for the determination of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic acid dehydrogenase.

Authors:  R J HENRY; N CHIAMORI; O J GOLUB; S BERKMAN
Journal:  Am J Clin Pathol       Date:  1960-10       Impact factor: 2.493

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  A method for rapid graphic solution of time-per cent effect curves.

Authors:  J T LITCHFIELD
Journal:  J Pharmacol Exp Ther       Date:  1949-12       Impact factor: 4.030

6.  Biochemical effects of 1,1-dichloroethylene in rats: dissociation of its hepatotoxicity from a lipoperoxidative mechanism.

Authors:  R J Jaeger; M J Trabulus; S D Murphy
Journal:  Toxicol Appl Pharmacol       Date:  1973-03       Impact factor: 4.219

7.  Effect of 18 hr fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats.

Authors:  R J Jaeger; R B Conolly; S D Murphy
Journal:  Exp Mol Pathol       Date:  1974-04       Impact factor: 3.362

8.  Effects on experimental animals of long-term inhalation of trichloroethylene, carbon tetrachloride, 1,1,1-trichloroethane, dichlorodifluoromethane, and 1,1-dichloroethylene.

Authors:  J A Prendergast; R A Jones; L J Jenkins; J Siegel
Journal:  Toxicol Appl Pharmacol       Date:  1967-03       Impact factor: 4.219

9.  Reversal of experimental paracetamol toxicosis with N-acetylcysteine.

Authors:  E Piperno; D A Berssenbruegge
Journal:  Lancet       Date:  1976-10-02       Impact factor: 79.321

10.  Protection by diethyldithiocarbamate against carbon tetrachloride lethality in rats and against carbon tetrachloride-induced lipid peroxidation in vitro.

Authors:  L M Lutz; E A Glende; R O Recknagel
Journal:  Biochem Pharmacol       Date:  1973-07-15       Impact factor: 5.858
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  2 in total

1.  Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.

Authors:  H Bartsch; C Malaveille; A Barbin; G Planche
Journal:  Arch Toxicol       Date:  1979-02-23       Impact factor: 5.153

Review 2.  A review: trichloroethylene metabolites: potential cardiac teratogens.

Authors:  P D Johnson; B V Dawson; S J Goldberg
Journal:  Environ Health Perspect       Date:  1998-08       Impact factor: 9.031
  2 in total

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