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Literature DB >> 6124358

Fasting-induced torpor in Mus musculus and its implications in the use of murine models for human obesity studies.

Abstract

1. Fasting at room temperature for 24-48 hr can induce shallow daily torpor in mice of several strains. 2. Genetically-obese (ob/ob) C57B1/6 mice show torpor even in the presence of food. 3. Chemically-obese (gold-thioglucose or bipiperidyl mustard) mice of C57B1/6 and T/O strains appear resistant to torpor. 4. During cold acclimation (3-5 degree) fasting also induces torpor in lean mice, with gradually improving rates of arousal. 5. In acute cold shock (3-5 degree), previously weight-reduced ob/ob mice show resistance to change in body temperature, while control ob/ob mice drift immediately towards hypothermia.

Entities: Chemical Disease Species

Mesh：

Year: 1982 PMID： 6124358 DOI： 10.1016/0300-9629(82)90035-4

Source DB: PubMed Journal: Comp Biochem Physiol A Comp Physiol ISSN： 0300-9629

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Cited

20 in total

1. Torpor patterns, arousal rates, and temporal organization of torpor entry in wildtype and UCP1-ablated mice.

Authors: R Oelkrug; G Heldmaier; C W Meyer
Journal: J Comp Physiol B Date: 2010-08-01 Impact factor: 2.200

2. The full expression of fasting-induced torpor requires beta 3-adrenergic receptor signaling.

Authors: Steven J Swoap; Margaret J Gutilla; L Cameron Liles; Ross O Smith; David Weinshenker
Journal: J Neurosci Date: 2006-01-04 Impact factor: 6.167

3. Dose-related steady states of fat loss in long-term leptin-treated ob/ob mice: leptin resistance or desensitization versus counterregulatory signaling.

Authors: Sandra Eiden; Eckhart Simon; Ingrid Schmidt
Journal: J Comp Physiol B Date: 2005-10-26 Impact factor: 2.200

10. MitoRACE: evaluating mitochondrial function in vivo and in single cells with subcellular resolution using multiphoton NADH autofluorescence.

Authors: T Bradley Willingham; Yingfan Zhang; Alessio Andreoni; Jay R Knutson; Duck-Yeon Lee; Brian Glancy
Journal: J Physiol Date: 2019-10-10 Impact factor: 6.228

Fasting-induced torpor in Mus musculus and its implications in the use of murine models for human obesity studies.

1. Torpor patterns, arousal rates, and temporal organization of torpor entry in wildtype and UCP1-ablated mice.

2. The full expression of fasting-induced torpor requires beta 3-adrenergic receptor signaling.

3. Dose-related steady states of fat loss in long-term leptin-treated ob/ob mice: leptin resistance or desensitization versus counterregulatory signaling.

4. Leptin regulation of core body temperature involves mechanisms independent of the thyroid axis.

5. Torpor in mice is induced by both leptin-dependent and -independent mechanisms.

6. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.

Review 7. Turn it off and on again: characteristics and control of torpor.

Review 8. Genetic identification of preoptic neurons that regulate body temperature in mice.

9. Cardiovascular changes during daily torpor in the laboratory mouse.

10. MitoRACE: evaluating mitochondrial function in vivo and in single cells with subcellular resolution using multiphoton NADH autofluorescence.