Literature DB >> 6124234

An overview of the genetics of psychopathology.

D R Petersen, A C Collins, R G Miles.   

Abstract

The suggestion that psychopathologies are in part mediated by aberrant catecholamine metabolism has resulted in one of the more rapidly growing areas of pharmacogenetics. Collectively, the studies conducted to date indicate that psychopathological conditions have multiple causes which cannot be related to single genetic or biochemical deficits. However, through multidisciplinary research integrating behavioral, genetic, and biochemical approaches, a great deal of insight may be gained concerning the causes of psychopathological disorders and the use of drug therapy to modify the course of these illnesses.

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Year:  1982        PMID: 6124234     DOI: 10.1007/bf01065737

Source DB:  PubMed          Journal:  Behav Genet        ISSN: 0001-8244            Impact factor:   2.805


  12 in total

1.  Genetic variation in activity of enzymes involved in synthesis of catecholamines.

Authors:  S Kessler; R D Ciaranello; J G Shire; J D Barchas
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

2.  Genetic control of platelet and plasma monoamine oxidase activity.

Authors:  A Nies; D S Robinson; K R Lamborn; R P Lampert
Journal:  Arch Gen Psychiatry       Date:  1973-06

3.  Genetic control of platelet monoamine oxidase activity: studies on normal families.

Authors:  G N Pandey; E Dorus; R Shaughnessy; J M Davis
Journal:  Life Sci       Date:  1979-09-24       Impact factor: 5.037

4.  Genetic analysis of serum dopamine-beta-hydroxylase activity in rats.

Authors:  J M Stolk; J H Hurst; D A Van Riper; P Q Harris
Journal:  Mol Pharmacol       Date:  1979-11       Impact factor: 4.436

5.  Relationships between neurotransmitter metabolism and behaviour in seven inbred strains of mice.

Authors:  G Tunnicliff; C C Wimer; R E Wimer
Journal:  Brain Res       Date:  1973-10-26       Impact factor: 3.252

6.  Catecholamines: strain differences in biosynthetic enzyme activity in mice.

Authors:  R D Ciaranello; R Barchas; S Kessler; J D Barchas
Journal:  Life Sci I       Date:  1972-06-15

7.  Genetic regulation of the catecholamine biosynthetic enzymes. II. Inheritance of tyrosine hydroxylase, dopamine-beta-hydroxylase, and phenylethanolamine N-methyltransferase.

Authors:  R D Ciaranello; H J Hoffman; J G Shire; J Axelrod
Journal:  J Biol Chem       Date:  1974-07-25       Impact factor: 5.157

Review 8.  Platelet monoamine oxidase activity in schizophrenia: a review of the data.

Authors:  R J Wyatt; S G Potkin; D L Murphy
Journal:  Am J Psychiatry       Date:  1979-04       Impact factor: 18.112

9.  Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia.

Authors:  R J Wyatt; D L Murphy; R Belmaker; S Cohen; C H Donnelly; W Pollin
Journal:  Science       Date:  1973-03-02       Impact factor: 47.728

10.  Genetic control of number of midbrain dopaminergic neurons in inbred strains of mice: relationship to size and neuronal density of the striatum.

Authors:  H Baker; T H Joh; D J Reis
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

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