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Literature DB >> 6124040

Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani.

R D Pearson, A A Manian, J L Harcus, D Hall, E L Hewlett.

Abstract

Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.

Entities: Chemical Disease Species

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Year: 1982 PMID： 6124040 DOI： 10.1126/science.6124040

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

16 in total

1. Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures.

Authors: T J Benson; J H McKie; J Garforth; A Borges; A H Fairlamb; K T Douglas
Journal: Biochem J Date: 1992-08-15 Impact factor: 3.857

2. Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.

Authors: Douglas M Ruderfer; Alexander W Charney; Ben Readhead; Brian A Kidd; Anna K Kähler; Paul J Kenny; Michael J Keiser; Jennifer L Moran; Christina M Hultman; Stuart A Scott; Patrick F Sullivan; Shaun M Purcell; Joel T Dudley; Pamela Sklar
Journal: Lancet Psychiatry Date: 2016-02-23 Impact factor: 27.083

Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani.

1. Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures.

2. Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.

Review 3. Thioridazine: resurrection as an antimicrobial agent?

4. Inhibitory effects of chlorpromazine on Candida species.

5. Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi.

6. Effect of calmodulin inhibitors on viability and mitochondrial potential of Plasmodium falciparum in culture.

7. Antileishmanial activity of chlorpromazine.

8. The effect of trifluoperazine (Stellazine) on Hymenolepis diminuta in vitro.

9. Susceptibility of Bordetella species to growth inhibition and killing by chlorpromazine.

10. Role of calmodulin and calcineurin in regulating flagellar motility and wave polarity in Leishmania.