Literature DB >> 6123958

Metabolism of oleoyl-CoA in rat brain synaptosomes: effects of calcium and post-decapitative ischemia.

J Strosznajder, W Tang, R Manning, A Y Lin, R MacQuarrie, G Y Sun.   

Abstract

The hydrolysis of acyl-CoA by acyl-CoA hydrolase (EC 3.1.2.2.) in brain synaptosomes was inhibited by calcium. This inhibition was partly due to interaction of Ca2+ with the acyl-CoA, which was present in the soluble form, and partly due to complex formation among acyl-CoA, Ca2+ and membrane phospholipids. The inhibition of acyl-CoA hydrolase activity, as well as the complex formation, could be reversed if incubation was carried out in the presence of Ca2+ chelating agents. Synaptosomes isolated from brain samples after 1 min of postdecapitative treatment showed a decrease in oleoyl-CoA hydrolase activity. The physiological implication of acyl-CoA metabolism in relation to synaptic function is discussed.

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Year:  1981        PMID： 6123958     DOI： 10.1007/bf00966680

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  14 in total

1.  Palmityl coenzyme A deacylase.

Authors:  P A SRERE; W SEUBERT; F LYNEN
Journal:  Biochim Biophys Acta       Date:  1959-06

2.  METABOLISM OF GLYCEROLIPIDS. VI. SPECIFICITIES OF ACYL COENZYME A: PHOSPHOLIPID ACYLTRANSFERASES.

Authors:  W E LANDS; P HART
Journal:  J Biol Chem       Date:  1965-05       Impact factor: 5.157

3.  Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids.

Authors:  A KORNBERG; W E PRICER
Journal:  J Biol Chem       Date:  1953-09       Impact factor: 5.157

4.  The long-chain fatty acyl-coenzyme A hydrolase activity of rat cerebral cortex.

Authors:  R W Bonser; G G Lunt
Journal:  Biochem Soc Trans       Date:  1976       Impact factor: 5.407

Review 5.  Molecular and physiological aspects of adenine nucleotide transport in mitochondria.

Authors:  P V Vignais
Journal:  Biochim Biophys Acta       Date:  1976-04-30

6.  Inhibition of bovine heart Na+, K+-ATPase by palmitylcarnitine and palmityl-CoA.

Authors:  J M Wood; B Bush; B J Pitts; A Schwartz
Journal:  Biochem Biophys Res Commun       Date:  1977-01-24       Impact factor: 3.575

7.  Aspects of long-chain acyl-COA metabolism.

Authors:  V A Tol
Journal:  Mol Cell Biochem       Date:  1975-04-30       Impact factor: 3.396

8.  Effects of atractyloside and palmitoyl coenzyme A on calcium transport in cardiac mitochondria.

Authors:  G K Asimakis; L A Sordahl
Journal:  Arch Biochem Biophys       Date:  1977-02       Impact factor: 4.013

9.  Brain acyl-coenzyme A hydrolase: distribution, purification and properties.

Authors:  A D Anderson; V G Erwin
Journal:  J Neurochem       Date:  1971-07       Impact factor: 5.372

10.  Changes in tissue levels of carnitine and other metabolites during myocardial ischemia and anoxia.

Authors:  A L Shug; J H Thomsen; J D Folts; N Bittar; M I Klein; J R Koke; P J Huth
Journal:  Arch Biochem Biophys       Date:  1978-04-15       Impact factor: 4.013
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  2 in total

1.  Calcium stimulation of glutamine hydrolysis in synaptosomes from rat brain.

Authors:  E Kvamme; G Svenneby; I A Torgner
Journal:  Neurochem Res       Date:  1983-01       Impact factor: 3.996

2.  Effects of postdecapitation ischemia on the metabolism of [14C]arachidonic acid and [14C]palmitic acid in the mouse brain.

Authors:  M F Pediconi; E B Rodriguez de Turco; N G Bazan
Journal:  Neurochem Res       Date:  1983-07       Impact factor: 3.996
  2 in total

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