Literature DB >> 6123457

Sulphasalazine and spermatogenesis.

J G Freeman, V A Reece, C W Venables.   

Abstract

The semen of 11 patients with inflammatory bowel disease treated with sulphasalazine (Salazopyrin) was analysed and compared with that of 6 men with similar disease not treated with the drug. The treated group had significantly reduced sperm population density and motility compared with the untreated group. Both groups had high numbers of abnormal spermatozoa compared with the standard for our laboratory, but there was no significant difference between the two groups for this parameter. Sulphasalazine has a deleterious effect on spermatogenesis.

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Year:  1982        PMID： 6123457     DOI： 10.1159/000198712

Source DB:  PubMed          Journal:  Digestion        ISSN： 0012-2823            Impact factor:   3.216


  7 in total

Review 1.  Sulfasalazine. Adverse effects and desensitization.

Authors:  S L Taffet; K M Das
Journal:  Dig Dis Sci       Date:  1983-09       Impact factor: 3.199

2.  Male fertility in Crohn's disease.

Authors:  D Burnell; J Mayberry; B J Calcraft; J S Morris; J Rhodes
Journal:  Postgrad Med J       Date:  1986-04       Impact factor: 2.401

3.  Effects of Different Drug Therapies and COVID-19 mRNA Vaccination on Semen Quality in a Man with Ankylosing Spondylitis: A Case Report.

Authors:  Katerina Chatzimeletiou; Alexandra Fleva; Antonia Sioga; Ioannis Georgiou; Theodoros-Thomas Nikolopoulos; Maria Markopoulou; Nikos Petrogiannis; George Anifandis; Antonios Patrikiou; Efstratios Kolibianakis; Anastasia Giannakou; Grigoris Grimbizis
Journal:  Medicina (Kaunas)       Date:  2022-01-24       Impact factor: 2.430

4.  Reversible male infertility due to sulphasalazine: studies in man and rat.

Authors:  C O'Moráin; P Smethurst; C J Doré; A J Levi
Journal:  Gut       Date:  1984-10       Impact factor: 23.059

5.  Sulphasalazine induced seminal abnormalities in ulcerative colitis: results of mesalazine substitution.

Authors:  S A Riley; J Lecarpentier; V Mani; M J Goodman; B K Mandal; L A Turnberg
Journal:  Gut       Date:  1987-08       Impact factor: 23.059

6.  Fertility potential in a man with ankylosing spondylitis as revealed by semen analysis by light, electron and fluorescence microscopy.

Authors:  Katerina Chatzimeletiou; Nikiforos Galanis; Alexandros Karagiannidis; Antonia Sioga; George Pados; Dimitrios Goulis; Antonis Kalpatsanidis; Basil C Tarlatzis
Journal:  SAGE Open Med Case Rep       Date:  2018-02-23

7.  The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review.

Authors:  L F Perez-Garcia; R J E M Dolhain; S Vorstenbosch; W Bramer; E van Puijenbroek; J M W Hazes; B Te Winkel
Journal:  Hum Reprod Update       Date:  2020-11-01       Impact factor: 15.610
  7 in total

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