| Literature DB >> 6123089 |
F A de Wolff, A C Peters, G M van Kempen.
Abstract
In a group of 59 epileptic children treated with phenytoin (PHT) and valproate sodium (VPA), either alone or in combination, the following effects were studied: (1) the reciprocal effect on the serum levels of the two drugs, and (2) the enzyme-inducing effects of both drugs. VPA had no effect on PHT levels, but PHT significantly decreased VPA concentrations. PHT enhanced both gamma-glutamyltranspeptidase activity (gamma-GT) and D-glucaric acid excretion (GLA); these effects were potentiated by VPA. VPA alone did not affect gamma-GT, but significantly enhanced GLA.Entities:
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Year: 1982 PMID： 6123089 DOI： 10.1055/s-2008-1059589
Source DB: PubMed Journal: Neuropediatrics ISSN： 0174-304X Impact factor: 1.947