Neuropharmacological supersensitivity-clinical and experimental correlates and methodological considerations.

The effects of chronic neuroleptic treatments on spontaneous and drug-induced locomotor activity and stereotypy is reviewed. The development of tolerance in relation to supersensitivity and its biochemical and clinical correlates are discussed, in addition to central neuropharmacological studies in this area. Proposed mechanisms of supersensitivity development are discussed and suggestions for further research made.