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Literature DB >> 6121712

Vasoactive intestinal peptide as a neurotransmitter in the cerebral circulation.

Abstract

Cat cerebral arteries exhibit a non-cholinergic neurogenic vasodilation which is absent in rabbit cerebral arteries. Levels of vasoactive intestinal peptide (VIP) measured by radioimmunoassay are correlated with the presence of a non-cholinergic vasodilation: 270 +/- 66 pmol/g in the cat anterior cerebral artery compared to 10 +/- 2.3 pmol/g in rabbit cerebral arteries. In the absence of endothelial cells, cat cerebral arteries do not relax to acetylcholine, but continue to relax to nerve stimulation. Relaxation responses to VIP also persist. These findings are consistent with the possibility that VIP mediates non-cholinergic vasodilator responses in the cerebral circulation.

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Year: 1982 PMID： 6121712 DOI： 10.1016/0014-2999(82)90041-3

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

12 in total

1. Effects of capsaicin on vascular smooth muscle.

Authors: S P Duckles
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1986-05 Impact factor: 3.000

Review 2. Parasympathetic innervation of vertebrobasilar arteries: is this a potential clinical target?

Authors: Eva V L Roloff; Ana M Tomiak-Baquero; Sergey Kasparov; Julian F R Paton
Journal: J Physiol Date: 2016-10-05 Impact factor: 5.182

3. Relaxation of cat tracheobronchial and pulmonary arterial smooth muscle by vasoactive intestinal peptide: lack of influence by peptidase inhibitors.

Authors: R J Altiere; L Diamond
Journal: Br J Pharmacol Date: 1984-06 Impact factor: 8.739

10. Changes of cerebral vasoactive intestinal polypeptide- and somatostatin-like immunoreactivity induced by noise and whole-body vibration in the rat.

Authors: H Nakamura; T Moroji; H Nagase; T Okazawa; A Okada
Journal: Eur J Appl Physiol Occup Physiol Date: 1994

Vasoactive intestinal peptide as a neurotransmitter in the cerebral circulation.

1. Effects of capsaicin on vascular smooth muscle.

Review 2. Parasympathetic innervation of vertebrobasilar arteries: is this a potential clinical target?

3. Relaxation of cat tracheobronchial and pulmonary arterial smooth muscle by vasoactive intestinal peptide: lack of influence by peptidase inhibitors.

4. Expression of VIP and its receptors in the testis of the spotted ray Torpedo marmorata (Risso 1880).

5. Endothelium-dependent and endothelium-independent vasodilatation of the hepatic artery of the rabbit.

6. A vasoactive intestinal peptide antagonist inhibits non-small cell lung cancer growth.

Review 7. Peptides in the mammalian cardiovascular system.

8. Innervation of the cerebral vasculature.

9. Heterogeneous vasomotor responses of anatomically distinct feline cerebral arteries.

10. Changes of cerebral vasoactive intestinal polypeptide- and somatostatin-like immunoreactivity induced by noise and whole-body vibration in the rat.