Literature DB >> 6119219

alpha 2-Adrenoceptor agonistic effect of B-HT 920 in isolated perfused hindquarters of rats.

W Kobinger, L Pichler.   

Abstract

In isolated perfused hindquarters of rats pretreated with reserpine the alpha 2-adrenoceptor selective agonist B-HT 920 decreased the flow dose-dependently. This effect was strongly antagonized by yohimbine and less by prazosin, and the reverse potency was demonstrated for methoxamine. With increasing concentrations of B-HT 920, a half maximal effect was achieved with 10(-6.64) M. This value is discussed wih respect to the antagonistic potency of B-HT 920 at alpha 1-adrenoceptors with a pA2 of 4.9.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6119219     DOI： 10.1016/0014-2999(81)90016-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Alpha-1 and alpha-2 adrenoceptor agonists induce vasoconstriction of the normotensive rat caudal artery in vitro by stimulation of a heterogeneous population of alpha-1 adrenoceptors.

Authors:  J Atkinson; N Trescases; C Benedek; N Boillat; A K Fouda; F Krause; M C Pitton; C Rafizadeh; J C de Rivaz; M Sautel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-11       Impact factor: 3.000

Review 2.  Rudolf Buchheim lecture. Drugs as tools in research on adrenoceptors.

Authors:  W Kobinger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-02       Impact factor: 3.000

3.  B-HT 958, a new alpha-adrenoceptor agonist with a high pre/postsynaptic activity ratio.

Authors:  L Pichler; H Hörtnagl; W Kobinger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-08       Impact factor: 3.000

4.  Hypotensive and bradycardic effects of talipexole (B-HT 920) in anaesthetized rabbits are antagonized by metoclopramide but not by yohimbine.

Authors:  R Palluk; J C Schilling; K Stockhaus; H Peil
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-07       Impact factor: 3.000

5.  B-HT 920 acts as an alpha 1-adrenoceptor agonist in the rabbit aorta under certain in vitro conditions.

Authors:  I Lues; H J Schümann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-01       Impact factor: 3.000

6.  Effects of basal and acetylcholine-induced release of endothelium-derived relaxing factor on contraction to alpha-adrenoceptor agonists in a rabbit artery and corresponding veins.

Authors:  J C McGrath; S Monaghan; A G Templeton; V G Wilson
Journal:  Br J Pharmacol       Date:  1990-01       Impact factor: 8.739
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.