| Literature DB >> 6116716 |
P B Antin, S Forry-Schaudies, T M Friedman, S J Tapscott, H Holtzer.
Abstract
Taxol has the following effects on myogenic cultures: (a) it blocks cell replication of presumptive myoblasts and fibroblasts. (b) It induces the aggregation of microtubules into sheets or massive cables in presumptive myoblasts and fibroblasts, but not in postmitotic, mononucleated myoblasts. (c) It induces normally elongated postmitotic myoblasts to form stubby, star-shaped cells. (d) It reversibly blocks the fusion of the star-shaped myoblasts into multinucleated myotubes. (e) It augments the number of microtubules in postmitotic myoblasts, and these are assembled into interdigitating arrays of microtubules and myosin filaments. (f) Actin filaments are largely excluded from these interdigitating microtubule-myosin complexes. (g) The myosin filaments in the interdigitating microtubule-myosin arrays are aligned laterally, forming A-bands approximately 1.5 micrometers long.Entities:
Mesh：
Substances：
Year: 1981 PMID： 6116716 PMCID： PMC2111880 DOI： 10.1083/jcb.90.2.300
Source DB: PubMed Journal: J Cell Biol ISSN： 0021-9525 Impact factor: 10.539