Literature DB >> 6116537

Cell-specific cytotoxicity expressed by a conjugate of ricin and murine monoclonal antibody directed against thy 1.1 antigen.

L L Houston, R C Nowinski.   

Abstract

The isolation and characterization are described of a conjugate between ricin, and a thy 1.1-specific monoclonal IgG2a murine antibody synthesized using N-succinimidyl-3-(2-pyridyldithio)propionate. The conjugate selectively inhibited protein synthesis in Thy 1.1-positive (AKR SL3) mouse leukemia cells compared to Thy 1.2-positive (AKR/Cu SL1) cells.

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Year:  1981        PMID： 6116537

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  4 in total

1.  Immunocytochemical detection of ricin. I. Preliminary immunofluorescence studies.

Authors:  H A Cmiech; M Morley; D J Gee
Journal:  Histochem J       Date:  1985-08

2.  Synergy of ricin A chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells.

Authors:  E S Vitetta; W Cushley; J W Uhr
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

3.  The antileukemic efficacy of an immunotoxin composed of a monoclonal anti-Thy-1 antibody disulfide linked to the ribosome-inactivating protein gelonin.

Authors:  C F Scott; V S Goldmacher; J M Lambert; R V Chari; S Bolender; M N Gauthier; W A Blättler
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

4.  A monoclonal antibody, KM10 reactive with human gastrointestinal cancer and its application for immunotherapy.

Authors:  H Ohyanagi; H Ishida; T Ishida; N Soyama; M Yamamoto; S Okumura; Y Kano; Y Ueda; Y Saitoh
Journal:  Jpn J Cancer Res       Date:  1988-12
  4 in total

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