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Literature DB >> 6115833

Localization of aminopeptidase A (angiotensinase A) in the rat and mouse kidney.

Abstract

Aminopeptidase A (E.C.3.4.11.7; APA) can be demonstrated histochemically in the rat and mouse kidney by light microscopy (simultaneous azo coupling with alpha-Glu-MNA as substrate and high-purity FBB as coupling agent) mainly in the brush borders, glomeruli and portions of the juxtaglomerular apparatus. Sex and species differences are found with regard to enzyme activity and localization. The relation of aminopeptidase A to angiotensinase A was established by inhibition experiments with angiotensin II and III. The following significant differences exist with respect to other aminopeptidases (aminopeptidase M and gamma-glutamyl transferase), which were also demonstrated: APM shows no dependence on calcium ions; APM and gamma-GT are not demonstrable in the glomerulus or juxtaglomerular apparatus.

Entities: Chemical Gene Species

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Year: 1981 PMID： 6115833 DOI： 10.1007/bf00517140

Source DB: PubMed Journal: Histochemistry ISSN： 0301-5564

17 in total

10. Ammoniagenesis catalyzed by hippurate-activated gamma-glutamyltransferase in the lumen of the proximal tubule. A microperfusion study in rat kidney in vivo.

Authors: S Silbernagl
Journal: Pflugers Arch Date: 1986 Impact factor: 3.657

Localization of aminopeptidase A (angiotensinase A) in the rat and mouse kidney.

1. ARYLAMIDASE ACTIVITY RELATED TO ANGIOTENSINASE.

2. A mammalian peptidase specific for the hydrolysis of N-terminal alpha-L-glutamyl and aspartyl residues.

3. [Significance of juxtaglomerular apparatus for the function of the nephron].

4. Purification of aminopeptidase A in human serum and degradation of angiotensin II by the purified enzyme.

5. [Quenching of tissue in liquid nitrogen-propane].

6. [Localization of aminopeptidase in tissue sections by a new immunofluorescent technic].

7. Study on aminopeptidase A.

8. [Structure and innervation of the juxtaglomerular apparatus of the rat (author's transl)].

9. Angiotensin II binding to renal glomeruli from sodium-loaded and sodium-depleted rats.

10. High affinity binding of 125I-angiotensin II to rat glomerular basement membranes.

1. Histochemical localization of kallikrein-like Pro-Phe-Arg-naphthylester esterase activity in the rat kidney.

2. Angiotensinase A in the renomedullary interstitial cells.

3. Immunocytochemical demonstration of renin in the mouse and rat kidney after adrenalectomy.

Review 4. Peptidases in the kidney and urine of rats after castration.

5. Histochemical demonstration of peptidases in the human kidney.

6. Histochemical demonstration of exopeptidases in the rat visceral yolk-sac epithelium.

7. Aminopeptidase A is angiotensinase A. II. Biochemical studies on aminopeptidase A and M in rat kidney homogenate.

8. The localization of converting enzyme in kidney vessels of the rat.

9. Histidine residue in the zinc-binding motif of aminopeptidase A is critical for enzymatic activity.

10. Ammoniagenesis catalyzed by hippurate-activated gamma-glutamyltransferase in the lumen of the proximal tubule. A microperfusion study in rat kidney in vivo.