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Literature DB >> 6115761

Role of neurotransmitter release and cyclic AMP-dependent membrane phosphorylation in low voltage myocardial automaticity.

M E Saxon, V G Safronova, A V Lazarev, A A Freidin, Y M Kokoz.

Abstract

Low voltage myocardial automaticity (LVA) was investigated by pharmacological modulations of the presynaptic and postsynaptic processes. The sensitivity of LVA both to inhibitor and stimulator of neurotransmitter release suggests its involvement in LVA genesis. Moreover, LVA is blocked by the inhibition of the cyclic AMP system, supporting the participation of the c-AMP-dependent membrane phosphorylation in calcium-mediated cardiac electrogenesis.

Entities: Chemical Disease Gene

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Year: 1981 PMID： 6115761 DOI： 10.1007/bf01967949

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

18 in total

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Authors: H Reuter
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Role of neurotransmitter release and cyclic AMP-dependent membrane phosphorylation in low voltage myocardial automaticity.

1. Effects of extracellular calcium and sodium on depolarization-induced automaticity in guinea pig papillary muscle.

2. Slow Ca2+ and Na+ responses induced by isoproterenol and methylxanthines in isolated perfused guinea pig hearts exposed to elevated K+.

3. Mechanisms contributing to malignant dysrhythmias induced by ischemia in the cat.

4. Cyclic AMP levels in ischaemic and non-ischaemic myocardium following coronary artery ligation: relation to ventricular fibrillation.

Review 5. Properties of two inward membrane currents in the heart.

6. Stimulation of 3',5'-cyclic AMP formation in dog myocardium following arrest of blood flow.

7. Electrically induced automaticity in ventricular myocardium.

8. Electrophysiological properties of the canine ventricular fiber.

9. Effects of extracellular potassium on ventricular automaticity and evidence for a pacemaker current in mammalian ventricular myocardium.

10. Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle.