Literature DB >> 6115493

The alpha-adrenergic blocking effect of prazosin on the human prostate.

A Shapiro, B Mazouz, M Caine.   

Abstract

The effect of prazosin on the adrenergic receptors in the human prostatic adenoma and prostatic capsule was investigated by an in vitro isometric technique. The results showed an alpha-adrenergic blocking action on both tissues. The cholinergic response of the capsule and the direct response of the adenoma were not affected. It is suggested that prazosin may prove preferable to phenoxybenzamine for clinical use as a prostatic alpha blocking agent, because of the selective action on the alpha1 receptors.

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Year:  1981        PMID： 6115493     DOI： 10.1007/bf00256833

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  7 in total

1.  Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck.

Authors:  M Caine; S Raz; M Zeigler
Journal:  Br J Urol       Date:  1975-04

2.  The pharmacology of antihypertensive drugs with special reference to vasodilators, alpha-adrenergic blocking agents and prazosin.

Authors:  D Cambridge; M J Davey; R Massingham
Journal:  Med J Aust       Date:  1977-08-20       Impact factor: 7.738

3.  Urinary incontinence caused by prazosin.

Authors:  T Thien; K P Delaere; F M Debruyne; R A Koene
Journal:  Br Med J       Date:  1978-03-11

4.  A placebo-controlled double-blind study of the effect of phenoxybenzamine in benign prostatic obstruction.

Authors:  M Caine; S Perlberg; S Meretyk
Journal:  Br J Urol       Date:  1978-12

5.  Physiologic evaluation of a new antihypertensive agent: prazosin HCl.

Authors:  M C Koshy; D Mickley; J Bourgiognie; M D Blaufox
Journal:  Circulation       Date:  1977-03       Impact factor: 29.690

6.  Cardiovascular effects of prazosin in dogs.

Authors:  I Cavero
Journal:  Clin Sci Mol Med Suppl       Date:  1976-12

7.  The use of alpha-adrenergic blockers in benign prostatic obstruction.

Authors:  M Caine; A Pfau; S Perlberg
Journal:  Br J Urol       Date:  1976-08
  7 in total
  5 in total

1.  Characterization of alpha 1-adrenoceptor subtypes in tension response of human prostate to electrical field stimulation.

Authors:  J H Guh; S C Chueh; F N Ko; C M Teng
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

2.  Are prostatic calculi independent predictive factors of lower urinary tract symptoms?

Authors:  Sung-Woo Park; Jong-Kil Nam; Sang-Don Lee; Moon-Kee Chung
Journal:  Asian J Androl       Date:  2009-12-07       Impact factor: 3.285

3.  Electrical and mechanical activity of rabbit prostate smooth muscles in response to nerve stimulation.

Authors:  N Seki; H Suzuki
Journal:  J Physiol       Date:  1989-12       Impact factor: 5.182

4.  Electrical and mechanical properties of the capsular smooth muscles of the rabbit prostate in relation to the actions of the alpha 1-adrenoceptor blocker, YM-12617.

Authors:  N Seki; E Nishiye; T Itoh; H Suzuki; H Kuriyama
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739

Review 5.  Age-related changes in the innervation of the prostate gland: implications for prostate cancer initiation and progression.

Authors:  Carl W White; Jin Han Xie; Sabatino Ventura
Journal:  Organogenesis       Date:  2013-05-14       Impact factor: 2.500
  5 in total

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