Literature DB >> 6115440

Failure of muscarinic blockade to antagonize analepsis induced by thyrotropin-releasing hormone and MK-771 in the rat.

E M Santori, D E Schmidt, P W Kalivas, A Horita.   

Abstract

In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It is not clear at this time whether the difference between our findings and these previous studies indicates a reduced sensitivity of cholinergic receptors in the rat to muscarinic blockade, a different neurochemical mechanism of action of TRH in the rat, or other unknown factors.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6115440     DOI： 10.1007/bf00431749

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  13 in total

1.  Neocortical and hippocampal activation relation to behavior: effects of atropine, eserine, phenothiazines, and amphetamine.

Authors:  C H Vanderwolf
Journal:  J Comp Physiol Psychol       Date:  1975-01

2.  Release of [3H]acetylcholine from rat hippocampal slices: effect of septal lesion and of graded concentrations of muscarnic agonists and antagonists.

Authors:  J C Szerb; P Hadházy; J D Dudar
Journal:  Brain Res       Date:  1977-06-10       Impact factor: 3.252

3.  Effects of thyrotropine releasing hormone (TRH) on pentobarbital-induced decrease in cholinergic neuronal activity.

Authors:  D E Schmidt
Journal:  Commun Psychopharmacol       Date:  1977

4.  Thydrotropin releasing hormone: antagonism of pentobarbital in rodents.

Authors:  A J Prange; G R Breese; J M Cott; B R Martin; B R Cooper; I C Wilson; N P Plotnikoff
Journal:  Life Sci       Date:  1974-02-01       Impact factor: 5.037

5.  Neuropharmacological consequences of choline administration.

Authors:  L Wecker; D E Schmidt
Journal:  Brain Res       Date:  1980-02-17       Impact factor: 3.252

6.  Muscarinic cholinergic binding in rat brain.

Authors:  H I Yamamura; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

7.  Intraventricular anti-cholinergics do not block cholinergic hippocampal RSA or neocortical desynchronization in the rabbit or rat.

Authors:  I Q Whishaw; T E Robinson; T Schallert
Journal:  Pharmacol Biochem Behav       Date:  1976-09       Impact factor: 3.533

8.  Studies on the neuropharmacology of thyrotropin releasing hormone (TRH) and a new TRH analog.

Authors:  G G Yarbrough
Journal:  Eur J Pharmacol       Date:  1978-03-01       Impact factor: 4.432

9.  Thyrotropin-releasing hormone: neurogenesis of actions in the pentobarbital narcotized rat.

Authors:  P W Kalivas; A Horita
Journal:  J Pharmacol Exp Ther       Date:  1980-02       Impact factor: 4.030

10.  Effect of thyrotropin-releasing hormone (TRH) on local cerebral glucose utilization, by the autoradiographic 2-deoxy[14C]glucose method, in conscious and pentobarbitalized rats.

Authors:  Y Nagai; S Narumi; Y Nagawa; O Sakurada; H Ueno; S Ishii
Journal:  J Neurochem       Date:  1980-10       Impact factor: 5.372
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.