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Literature DB >> 6113866

The role of the local anaesthetic properties of beta-adrenoceptor blocking agents in antagonizing CaCl2-induced arrhythmias in the rat.

Abstract

1 Eight beta-adrenoceptor blocking agents were compared for their ability to antagonize arrhythmias induced by bolus injections of CaCl2 in rats. 2 Only those beta-blockers possessing local anaesthetic properties were effective in antagonizing this type of arrhythmia and there was a highly significant correlation between antiarrhythmic and local anaesthetic properties. 3 Effects on adrenoceptors seem to play only a minor role in the genesis of this type of arrhythmia.

Entities: Chemical Disease Species

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Year: 1981 PMID： 6113866 PMCID： PMC2071696 DOI： 10.1111/j.1476-5381.1981.tb16808.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

13 in total

1. THE ANTIARRHYTHMIC ACTIONS OF BETA ADRENERGIC BLOCKING AGENTS.

Authors: P SOMANI; B K LUM
Journal: J Pharmacol Exp Ther Date: 1965-02 Impact factor: 4.030

2. THE EFFECTS OF PRONETHALOL AND ITS DEXTRO ISOMER UPON EXPERIMENTAL CARDIAC ARRHYTHMIAS.

Authors: B R LUCCHESI
Journal: J Pharmacol Exp Ther Date: 1965-04 Impact factor: 4.030

3. A simple new quantitative method for testing local anaesthetics.

Authors: C BIANCHI
Journal: Br J Pharmacol Chemother Date: 1956-06

4. Nervous mechanisms in ventricular arrhythmias induced by calcium chloride in rats.

Authors: M R MALINOW; F F BATLLE; B MALAMUD
Journal: Circ Res Date: 1953-11 Impact factor: 17.367

Review 5. Ionic mechanisms in heart muscle in relation to the genesis and the pharmacological control of cardiac arrhythmias.

Authors: O Hauswirth; B N Singh
Journal: Pharmacol Rev Date: 1978-03 Impact factor: 25.468

6. Investigations on the pathogenesis of calcium-induced cardiac arrhythmias in dogs.

Authors: B Cuparencu; I Ticsa; V Csutak; V I Sandor; T Bârzu; L Safta; D Trung Dam
Journal: Agressologie Date: 1978

7. Effect of beta receptor blockade on the initiation and perpetuation of ouabain-induced ventricular tachyarrhythmia.

Authors: F O Apantaku; C M Baumgarten; R E Ten Eick
Journal: J Pharmacol Exp Ther Date: 1975-05 Impact factor: 4.030

8. Local anaesthetic and anti-arrhythmic actions of alprenolol relative to its effect on intracellular potentials and other properties of isolated cardiac muscle.

Authors: B N Singh; E M Williams
Journal: Br J Pharmacol Date: 1970-04 Impact factor: 8.739

The role of the local anaesthetic properties of beta-adrenoceptor blocking agents in antagonizing CaCl2-induced arrhythmias in the rat.

1. THE ANTIARRHYTHMIC ACTIONS OF BETA ADRENERGIC BLOCKING AGENTS.

2. THE EFFECTS OF PRONETHALOL AND ITS DEXTRO ISOMER UPON EXPERIMENTAL CARDIAC ARRHYTHMIAS.

3. A simple new quantitative method for testing local anaesthetics.

4. Nervous mechanisms in ventricular arrhythmias induced by calcium chloride in rats.

Review 5. Ionic mechanisms in heart muscle in relation to the genesis and the pharmacological control of cardiac arrhythmias.

6. Investigations on the pathogenesis of calcium-induced cardiac arrhythmias in dogs.

7. Effect of beta receptor blockade on the initiation and perpetuation of ouabain-induced ventricular tachyarrhythmia.

8. Local anaesthetic and anti-arrhythmic actions of alprenolol relative to its effect on intracellular potentials and other properties of isolated cardiac muscle.

9. The relevance of beta-receptor blockade to ouabain-induced cardiac arrhythmias.

10. Comparative myocardial depressant and anti-arrhythmic properties of d-propranolol, dl-propranolol and quinidine.

1. Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs.

2. Comparison of verapamil and bepridil, two slow channel inhibitors, in protection against calcium-induced arrhythmias.