| Literature DB >> 6113206 |
M Mukherjea, P Mukherjee, R Biswas, A S Chakraborty, J Kushari.
Abstract
Activities of five enzymes were determined biochemically in the serum of a woman taking the injectable contraceptive, depo-medroxyprogesterone acetate (DMPA), 150 mg every 3 months for 2 years. The specific activities of SGOT, SGPT, and alkaline phosphatase (AP)-the enzymes commonly discerned in tests on the function of the liver-do not show any change with long-term treatment of this steroid contraceptive. Activities of serum acid phosphatase (ACP) and acetylcholinesterase (AChE) in red cells show significant increase. DMPA contraception has no apparent harmful effect on liver function, although the rise in ACP and AChE activities may be related to some pathological condition.Entities:
Keywords: Asia; Biology; Clinical Research; Contraception; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Developing Countries; Enzymatic Effects; Enzymes And Enzyme Inhibitors; Family Planning; Follow-up Studies; Hepatic Effects; Human Volunteers; India; Injectables; Medroxyprogesterone Acetate--side effects; Physiology; Research Methodology; Southern Asia; Studies
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Year: 1981 PMID： 6113206
Source DB: PubMed Journal: Int J Fertil ISSN： 0020-725X