| Literature DB >> 6112273 |
Abstract
A variety of neuropharmacological agents were tested to elucidate how chlorpromazine influenced an endotoxin-induced reaction. The results obtained, particularly with beta-adrenergic blocking agents, reserpine and fusaric acid, suggested that the primary locus of chlorpromazine's action was mediated by peripheral beta-adrenergic receptor blockade. Such a locus is compatible with the low doses of propranolol which suppress the reaction, and with successful treatment of shock with dopamine.Entities:
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Year: 1980 PMID： 6112273 PMCID： PMC1437605 DOI： 10.1177/014107688007300608
Source DB: PubMed Journal: J R Soc Med ISSN： 0141-0768 Impact factor: 18.000