Literature DB >> 6112061

The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures.

G S Probst, S B Neal.   

Abstract

The autoradiographic identification of chemically-induced, unscheduled DNA synthesis in primary cultures of adult rat hepatocytes is currently being validated as a predictive test for mutagens/carcinogens. Of 8 antihistaminic drugs tested, 2, pyrilamine maleate and tripelennamine HCl, were positive for unscheduled DNA synthesis. Further investigation of the mutagenic/carcinogenic potential of these compounds in alternate test systems is suggested.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6112061     DOI： 10.1016/0304-3835(80)90067-1

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  3 in total

1.  Use of scintillometric quantitation of unscheduled DNA synthesis in isolated rat hepatocytes for the screening of genotoxic agents.

Authors:  M T Hsia
Journal:  Cell Biol Toxicol       Date:  1987-06       Impact factor: 6.691

2.  Quantitative predictivity of carcinogenicity of the autoradiographic repair test (primary hepatocyte cultures) for a group of 80 chemicals belonging to different chemical classes.

Authors:  C Bolognesi; M Taningher; S Parodi; L Santi
Journal:  Environ Health Perspect       Date:  1986-12       Impact factor: 9.031

3.  Choline deficient diet enhances the initiating and promoting effects of methapyrilene hydrochloride in rat liver as assayed by the induction of gamma-glutamyltranspeptidase-positive hepatocyte foci.

Authors:  M I Perera; S L Katyal; H Shinozuka
Journal:  Br J Cancer       Date:  1987-12       Impact factor: 7.640
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.