Literature DB >> 6111538

Propagation of Korean hemorrhagic fever virus in laboratory rats.

P W Lee, H L Amyx, C J Gibbs, D C Gajdusek, H W Lee.   

Abstract

Korean hemorrhagic fever virus (KHFV) has been adapted to the Wistar and Fisher strains of rats. Infection was detected by the appearance of specific antigen in the lung tissue of the infected rats at 14 to 64 days after inoculation and by the appearance of circulating antibodies in ther serum which reacted specifically with KHFV antigen in the lungs of infected Apodemus agrarius subsp. coreae 3 weeks after inoculation. Distribution of antigen in rat tissues as determined by immunofluorescent staining was the same as that in Apodemus mice except that antigen was present in the spleens of rats. Adaptation of KHFV to the laboratory rat provides an animal model that is free of wild rodent viruses and is readily available for use in studies on the characterization of KHFV.

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Year:  1981        PMID： 6111538      PMCID： PMC351787          DOI： 10.1128/iai.31.1.334-338.1981

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

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3.  The clinical course of epidemic hemorrhagic fever.

Authors:  J A SHEEDY; H F FROEB; H A BATSON; C C CONLEY; J P MURPHY; R B HUNTER; D W CUGELL; R B GILES; S C BERSHADSKY; J W VESTER; R H YOE
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4.  Epidemic hemorrhagic fever.

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Journal:  Am J Public Health Nations Health       Date:  1953-10

5.  Hemorrhagic fever with renal syndrome: report of 11 observations.

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7.  Aetiological relation between Korean haemorrhagic fever with renal syndrome in People's Republic of China.

Authors:  P W Lee; D C Gajdusek; C J Gibbs; Z Y Xu
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8.  Virus hemorrhagic fevers. Special reference to hemorrhagic fever with renal syndrome (epidemic hemorrhagic fever).

Authors:  D C GAJDUSEK
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9.  Aetiological relation between Korean haemorrhagic fever and nephropathia epidemica.

Authors:  H W Lee; P W Lee; J Lähdevirta; M Brummer-Korventkontio
Journal:  Lancet       Date:  1979-01-27       Impact factor: 79.321

10.  Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection.

Authors:  M Brummer-Korvenkontio; A Vaheri; T Hovi; C H von Bonsdorff; J Vuorimies; T Manni; K Penttinen; N Oker-Blom; J Lähdevirta
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  15 in total

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2.  Epidemiologic characteristics of haemorrhagic fever with renal syndrome in Mainland China from 2006 to 2010.

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Authors:  K Dohmae; Y Nishimune
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4.  Differential susceptibility and resistance of immunocompetent and immunodeficient mice to fatal Hantaan virus infection.

Authors:  T Nakamura; R Yanagihara; C J Gibbs; H L Amyx; D C Gajdusek
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5.  Age-dependent transmission of hemorrhagic fever with renal syndrome (HFRS) virus in rats. Brief report.

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7.  Pathogenesis of experimental Hantaan virus infection in laboratory rats.

Authors:  P W Lee; R Yanagihara; C J Gibbs; D C Gajdusek
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8.  Efficacy of arbidol on lethal hantaan virus infections in suckling mice and in vitro.

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9.  Immunofluorescence studies of disseminated Hantaan virus infection of suckling mice.

Authors:  T Kurata; T F Tsai; S P Bauer; J B McCormick
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10.  Antiviral neutralizing antibody to Hantaan virus as determined by plaque reduction technique.

Authors:  A Takenaka; C J Gibbs; D C Gajdusek
Journal:  Arch Virol       Date:  1985       Impact factor: 2.574
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