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Literature DB >> 6110804

[Electrophysiological classification of newer antiarrhythmic drugs (author's transl)].

Abstract

Newer antiarrhythmic drugs are tentatively classified on the basis of their influence on the transmembrane action potential, the fast sodium inward current and its kinetics, and the slow inward current which is primarily carried by calcium ions. Disopyramide is probably a quinidine-like antiarrhythmic drug, while the effects of aprindine, lorcainide, and tocainide resemble those of lidocaine. Mexiletine and propafenon cannot be classified definitely on the basis of the hitherto available electrophysiological data. Besides their effects on the fast inward current these substances may have additional calcium antagonistic properties.

Entities: Chemical

Mesh：

Substances：

Year: 1980 PMID： 6110804 DOI： 10.1007/bf01477048

Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173

71 in total

1. Electrophysiology and pharmacology of cardiac arrhythmias. VII. Cardiac effects of quinidine and procaine amide. A.

Authors: B F Hoffman; M R Rosen; A L Wit
Journal: Am Heart J Date: 1975-06 Impact factor: 4.749

2. Effects of calcium ions and local anesthetics on electrical properties of Purkinje fibres.

Authors: S WEIDMANN
Journal: J Physiol Date: 1955-09-28 Impact factor: 5.182

Review 3. Electrophysiology and pharmacology of cardiac arrhythmias. I. Cellular electrophysiology of the mammalian heart.

Authors: M R Rosen; A L Wit; B F Hoffman
Journal: Am Heart J Date: 1974-09 Impact factor: 4.749

4. Effects of agents which inhibit the slow channel on sinus node automaticity and atrioventricular conduction in the dog.

Authors: D P Zipes; J C Fischer
Journal: Circ Res Date: 1974-02 Impact factor: 17.367

5. [Pharmacology of 2'-[2-hydroxy-3-(propylamino)-propoxy]-3-phenylpropiophenone (Propafenone, SA 79)-hydrochloride].

Authors: H J Hapke; E Prigge
Journal: Arzneimittelforschung Date: 1976

6. Reentrant ventricular arrhythmias in the late myocardial infarction period. 7. Effect of verapamil and D-600 and the role of the "slow channel".

Authors: N El-Sherif; R Lazzara
Journal: Circulation Date: 1979-09 Impact factor: 29.690

Review 10. Electrophysiology and pharmacology of cardiac arrhythmias. II. Relationship of normal and abnormal electrical activity of cardiac fibers to the genesis of arrhythmias b. Re-entry. Section II.

Authors: A L Wit; M R Rosen; B F Hoffman
Journal: Am Heart J Date: 1974-12 Impact factor: 4.749

1 in total

1. Effects on transmembrane action potential, slow inward current and force of contraction in ventricular cardiac muscle of BRL 31660, a new antiarrhythmic drug with class I and class IV activity.

Authors: R Brückner; W Schmitz; H Scholz
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1985-03 Impact factor: 3.000